Platelet-Rich Plasma à la Carte
TLDR Platelet-rich plasma (PRP) shows no significant benefit for bone and soft-tissue injuries or wound healing, and its effectiveness may improve with customization.
The commentary on Satoshi Terada et al.'s article discussed the limitations and potential of Platelet-Rich Plasma (PRP) in musculoskeletal healing. Despite its widespread use, meta-analyses indicated PRP provided no significant benefit for bone and soft-tissue injuries, partly due to the variability in PRP composition and poor quality of clinical studies. Terada et al. proposed customizing PRP for specific indications, demonstrated in a murine model where PRP combined with losartan improved muscle healing by enhancing angiogenesis and reducing fibrosis. This approach suggested potential for personalized PRP treatments, though further research on optimal dosing and application is needed.
