research Apremilast and Tofacitinib Exert Differential Effects in the Humanized Mouse Model of Alopecia Areata
Tofacitinib was more effective than apremilast in treating hair loss in a mouse model of alopecia areata.
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research Social Pharmacology: Integrating Pharmaceutical and Social Science Research on Drug Effects
The conclusion is that combining social and cultural factors with pharmaceutical research could improve our understanding of how drugs work.
research Phytochemistry, pharmacological activity, and potential health benefits of Glycyrrhiza glabra
The review on Glycyrrhiza glabra, commonly known as licorice, highlighted its diverse phytochemical constituents, including glycyrrhizin and glycyrrhizic acid, which exhibited various pharmacological activities. These compounds were noted for their anti-cancer, anti-inflammatory, anti-microbial, and antispasmodic properties, among others. Additionally, licorice showed potential health benefits such as stimulating hair growth, controlling obesity, and providing hepatoprotective and memory-enhancing effects. The review also addressed the side effects and toxicity associated with licorice and its bioactive components.
research A9. Excess hair: physical and pharmacological treatments
The document discussed the effectiveness of modern physical and pharmacological methods for unwanted hair removal, highlighting laser technology and pharmacological treatments like Eflornithine. Laser treatments, using selective photothermolysis, targeted pigmented hair bulbs, causing thermal damage and resulting in thinner, softer regrowth, with effects lasting around 8 months after an average of 2 sessions. Eflornithine, a topical cream, reduced hair growth by at least 50% over prolonged use by blocking an enzyme essential for hair shaft synthesis. These methods were more effective than traditional mechanical and chemical hair removal techniques.
research Cepharanthine: An Update of Its Mode of Action, Pharmacological Properties, and Medical Applications
Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.
research An Open-Label Prospective Observational Study of Antiandrogen and Non-Antiandrogen Early Pharmacological Approaches in Females with Mild-to-Moderate COVID-19: The Pre-AndroCoV Female Trial
Early treatment improved COVID-19 outcomes, and spironolactone helped reduce risks in females with high androgen levels.
research Hair Loss – Surgical and Pharmacological Treatment
Hair loss can be treated with medications like finasteride and surgical methods like hair transplants.
research Fissistigma Oldhamii (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects
Fissistigma oldhamii has compounds that help with pain, inflammation, and other health issues.
research Systematic Review: Interventions in Sickle Cell Disease-Related Priapism in Reducing Overall Morbidity, Recurrence, and Side Effects
More research is needed to find effective treatments for sickle cell disease-related priapism.
research Antioxidants in Dermatology
Antioxidants can benefit skin health but should be used carefully to avoid negative effects.
research Practical Management of Hidradenitis Suppurativa
Early diagnosis and treatment of Hidradenitis Suppurativa are important to prevent serious physical and mental effects.
research Review of Fluconazole Properties and Analytical Methods for Its Determination
Fluconazole is an effective antifungal medication with potential side effects and lacks official analytical methods for its determination.
research Pharmacologic Modulation of Sebaceous Gland Activity: Mechanisms and Clinical Applications
The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.
research Steroid Hormones of Reproduction and Sexual Development
Sex hormones affect reproduction, sexual development, and oral health, and it's important for dental practitioners to understand their effects and interactions.
research Metformin in Dermatology: An Overview
Metformin is effective for various skin disorders but may cause skin side effects.
research Hirsuties
Hirsutism in women is often due to hormone sensitivity and has significant psychological effects.
research Neem (Azadirachta Indica): A Panacea of All Diseases
Neem is highly beneficial for health and beauty with no major side effects.
research Multicentric Parallel Phase II Trial of the Polo-Like Kinase 1 Inhibitor BI 2536 in Patients With Advanced Head and Neck Cancer, Breast Cancer, Ovarian Cancer, Soft Tissue Sarcoma, and Melanoma. The First Protocol of the European Organization for Research and Treatment of Cancer Network of Core Institutes
BI 2536 had limited effectiveness against several advanced cancers and caused significant side effects.
research Comparing Current Therapeutic Modalities of Androgenic Alopecia: A Literature Review of Clinical Trials
Some treatments for hereditary hair loss are effective but vary in results and side effects; new therapies show promise but need more research.
research Updates on Hirsutism: A Narrative Review
The review suggests a comprehensive approach to treat hirsutism, focusing on hair removal, medication, and managing emotional effects.
research Treatment of Female Sexual Dysfunction in Postmenopausal Women: What Is the Evidence?
Hormonal changes and psychological issues can cause sexual dysfunction in postmenopausal women. Behavioral therapy is recommended first, with hormone replacement helping some symptoms but not libido. Testosterone can improve libido, but its effects on overall sexual function are unclear. Emotional and relationship issues should be addressed before using medication, and the benefits and risks of testosterone supplementation should be considered.
research The Important Role of Leptin in Modulating the Risk of Dermatological Diseases
Leptin, a hormone from fat cells, affects immune responses and can influence skin diseases and hair growth.
research The Use of Essential Oils in the Development of Dermato-Cosmetic Products
Essential oils are increasingly used in cosmetics for their natural benefits but must be used carefully to avoid skin reactions.
research Best Practice Options for Hair Removal in Patients with Unwanted Facial Hair Using Combination Therapy with Laser: Guidelines by an Expert Working Group
Combining laser hair removal with topical eflornithine is recommended for better results in treating unwanted facial hair.
research The Latest Options and Future Agents for Treating Male Hypogonadism
New and future treatments for male hypogonadism include various forms of testosterone therapy and emerging drugs.
research Therapy of Hypertrichosis
Individualized treatment plans are crucial for managing excessive hair growth.
research Occult Fungal Infection as the Underlying Pathogenic Cause of Atherogenesis
Hidden fungal infections might cause heart disease and clogged arteries.
research Androgenetic Alopecia in Al-Qalyubia Governorate: A Comprehensive Review
Current treatments for androgenetic alopecia manage symptoms but don't cure it, and it affects social and psychological well-being.
research Rely on Clinical Experience to Guide Treatment Selection for Primary Cicatricial Alopecias
Doctors use their experience to choose treatments for scarring hair loss because it's hard to diagnose and treat.
research Chemotherapy-Induced Alopecia
Many patients find hair loss from chemotherapy very distressing, and while treatments like minoxidil and scalp cooling may help, there is no sure way to prevent it.