Formulation Development, Pharmacological Evaluation, and Characterization of Eclipta Alba Phytosomes

The study developed phytosomes of Eclipta alba to improve its bioavailability and therapeutic efficacy. Eclipta alba, known for its hepatoprotective, anti-inflammatory, and antioxidant properties, has poor solubility and low bioavailability. By forming phytosomes with phospholipids, the study achieved a particle size of 150 nm, a zeta potential of -30 mV, and an encapsulation efficiency of 85%, indicating good stability. The phytosomes showed superior in vitro antioxidant activity with IC50 values of 12.5 μg/mL and 15 μg/mL in DPPH and ABTS assays, respectively, compared to the free extract. In vivo studies demonstrated significant anticancer effects, suggesting enhanced therapeutic efficacy through improved bioavailability and pharmacological activities.