June 2025 in “Pharmaceuticals” This study analyzed reports from the FDA Adverse Event Reporting System and observed an upward trend in suicidality-related safety signals among young male finasteride users since 2019, peaking in 2022, highlighting emerging psychiatric safety concerns and the need for vigilant monitoring of this population.
1 citations
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August 2024 in “Expert Opinion on Drug Safety” This study analyzed data from the FDA Adverse Event Reporting System and found that finasteride had the highest reporting frequency and signal strength for drug-induced erectile dysfunction among 734 drugs, with compound preparations posing higher risks than single ingredients.
13 citations
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December 2012 in “Canadian Urological Association Journal” This report from a consensus meeting concluded that while 5-alpha reductase inhibitors are beneficial for BPH treatment and prostate cancer risk reduction, their role in clinical practice should be more widely integrated into prostate management guidelines.
5 citations
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January 2018 in “PubMed” This article discusses the ethical views of Polish physicians on performance-enhancing substances and emphasizes the need to improve their knowledge to better address related issues in their patients, but it reports no new results.
November 2022 in “International Journal of Trichology” This case study reports a 25-year-old male developing an extensive psoriasiform eruption within a week after starting finasteride 1 mg for androgenetic alopecia.
August 2021 in “Annals of Agricultural and Environmental Medicine” This review provides a detailed analysis of frontal fibrosing alopecia, focusing on its prevalence in postmenopausal Caucasian women, associated comorbidities, and potential autoimmune, genetic, hormonal, and environmental factors; it emphasizes the need for improved understanding to enhance diagnosis and treatment.
April 2016 in “The Journal of Sexual Medicine” This report analyzed an FDA adverse event database and aimed to evaluate and describe post-finasteride syndrome potentially related to dutasteride, but it does not report new clinical findings.
February 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This paper proposes a novel theory that certain symptoms of Post-Finasteride Syndrome may be caused by an overgrowth of hydrogen sulphide-producing bacteria in the small intestine, which acts as a mitochondrial toxin, with implications for treatment targeting the gut microbiome.
14 citations
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March 2023 in “Scientific Reports” This study found that in women with polycystic ovary syndrome, PCOS phenotype and oxidative stress markers were significantly related to free androgen index levels, but insulin resistance was not.
5 citations
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September 2014 in “Journal of Pharmaceutical Sciences” 1 citations
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December 2009 in “Asian Journal of Research in Chemistry” This study developed and validated ultraviolet spectrophotometric and reversed phase high performance liquid chromatographic methods for simultaneously estimating Tamsulosin and Finasteride in tablet form, showing statistical validation and effectiveness in pharmaceutical analysis.
1 citations
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November 2023 in “Contact dermatitis” In this study, sensitization to ethylhexyl salicylate was found in 27.3% of patients with frontal fibrosing alopecia, suggesting it may be a potential contact allergen for this condition.
March 2026 in “Dermatology Reports” This study found that frontal fibrosing alopecia had higher long-term remission rates compared to lichen planopilaris, highlighting differences in their clinical presentations and outcomes.
8 citations
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October 2021 in “The international journal of risk and safety in medicine” This paper describes the development of diagnostic criteria for several enduring sexual dysfunction conditions following the use of certain medications, highlighting common sexual and non-sexual symptoms.
16 citations
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January 2017 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” This case study discusses a postmenopausal woman's frontal fibrosing alopecia and lichen planus pigmentosus, controlled with corticosteroids and finasteride, highlighting diagnostic and therapeutic challenges in scarring alopecia.
March 2023 in “The Journal of Urology” This study found that higher baseline expression of SRD5A2 in prostate tissue was associated with a better response to finasteride in men with benign prostatic hyperplasia.
April 2026 in “Brain Sciences” This pharmacovigilance study analyzed FAERS data and found that finasteride is more frequently associated with neuropsychiatric reactions like depression and suicide risk, especially in younger men using it for alopecia, compared to dutasteride.
September 2004 in “Inpharma Weekly”
October 2022 in “Rheumatology (Bulgaria)” This case report details the challenging diagnostic journey of a 50-year-old woman with progressive supranuclear palsy, highlighting the disease's complex and variable clinical presentation.
1 citations
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August 2018 in “Journal of the American Academy of Dermatology” A young woman developed facial bumps before hair loss, which is unusual for her condition.
January 2008 in “Journal of Medicinal Chemistry” This study suggests that finasteride may inhibit the enzyme phenylethanolamine N-methyltransferase, which could contribute to its sexual and psychological side effects.
81 citations
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June 2014 in “American Journal of Men's Health” This study highlights that adverse effects from finasteride may persist in men after discontinuation, indicating a potential "post-finasteride syndrome.
January 2009 in “The Hastings Center Report” This review discusses the preventive use of finasteride for prostate cancer and highlights the unresolved safety concerns and potential over-diagnosis associated with its widespread recommendation.
1 citations
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June 2025 in “Journal of Clinical Medicine” This study reported that frontal fibrosing alopecia predominantly affects postmenopausal women and identified potential risk factors like frequent β-blocker use and sunscreen application, indicating the need for further research.
July 2004 in “Current Urology Reports”
February 2026 in “PubMed” In this study, adult male rats exhibited significant anxiety-like behaviors following finasteride withdrawal, including pronounced hyperactivity and novelty avoidance, highlighting potential parallels with post-finasteride syndrome observed in clinical settings.
May 2025 in “Zagazig Journal of Pharmaceutical Sciences/Zagazig Journal of Pharmaceutical Science” In laboratory settings, this study found that finasteride repurposed as a quorum sensing inhibitor significantly reduced virulence factors of Pseudomonas aeruginosa, including biofilm formation by 45% and pyocyanin production by 49%, suggesting potential for treating infections.
42 citations
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February 1998 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that PNU 157706 is a highly potent inhibitor of human 5α-reductase enzymes, showing a stronger and longer-lasting antiprostatic effect in rats compared to finasteride.
1 citations
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August 2023 in “South Asian Research Journal of Pharmaceutical Sciences” This study examined the relationship between asprosin levels and polycystic ovary syndrome, finding no statistically significant difference in asprosin levels between patients and healthy controls, although differences in fetuin a levels were significant.
57 citations
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January 2003 in “Clinical and experimental dermatology” This study identified postmenopausal frontal fibrosing alopecia as a distinct form of scarring alopecia in postmenopausal women, noting a potential link with a history of bilateral oophorectomy.