PCPT, MTOPS and the Use of 5ARIs: A Canadian Consensus Regarding Implications for Clinical Practice

December 2012 in “ Canadian Urological Association Journal ”

Laurence Klotz, Fred Saad

5-alpha reductase inhibitors finasteride benign prostatic hyperplasia prostate cancer lower urinary tract symptoms 5ARIs Propecia BPH LUTS

TLDR 5ARIs like finasteride can help prevent prostate cancer and treat BPH, but guidelines should be updated to reflect this.

The Canadian consensus on the use of 5-alpha reductase inhibitors (5ARIs) was based on findings from the Prostate Cancer Prevention Trial (PCPT) and the Medical Therapy of Prostatic Symptoms (MTOPS), which showed positive results for finasteride in preventing prostate cancer and treating benign prostatic hyperplasia (BPH). The consensus recommended updating prostate management guidelines to reflect these findings. It was noted that the PCPT showed a higher incidence of high-grade cancer in the finasteride group, likely due to detection bias from reduced prostate volume. The consensus suggested considering 5ARIs for men with large prostates and lower urinary tract symptoms (LUTS) and discussing chemoprevention with finasteride for those concerned about prostate cancer. Urologists were encouraged to share these recommendations with other healthcare professionals.

View this study on cuaj.ca →

Discuss this study in the Community →

Similar Research

6 / 1000+ results

research Inhibitors of 5α-Reductase in the Treatment of Benign Prostatic Hyperplasia

52 citations , February 2006 in “Current pharmaceutical design”

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.

research Finasteride

40 citations , April 1999 in “Drugs”

Finasteride treats enlarged prostate, improves urinary flow, but may cause sexual side effects.

research Adverse Effects of 5-Alpha Reductase Inhibitor Therapy in Men With Androgenetic Alopecia: Is There Cause for Concern?

1 citations , September 2016 in “Actas Dermo-Sifiliográficas”

5-alpha reductase inhibitors may cause sexual side effects, breast complications, and other health risks in men with hair loss.

research Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride

50 citations , March 2017 in “PeerJ”

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

research What Do We Know About Phytotherapy of Benign Prostatic Hyperplasia?

67 citations , February 2015 in “Life Sciences”

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

research Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

223 citations , December 2010 in “The Journal of Sexual Medicine”

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

PCPT, MTOPS and the Use of 5ARIs: A Canadian Consensus Regarding Implications for Clinical Practice

Related Community Posts Join

community I interviewed Kintor: GT20029 Clinical Trial Pictures. As well as KX826.

community Sexual Dysfunction in Those with Androgenetic Alopecia on Dutasteride Versus Finasteride

community Hair Loss Drugs Ranked in Order of Efficacy

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

community Wtf have we been doing for the last 30 years