Repurposing Finasteride as a Quorum Sensing Inhibitor in Pseudomonas Aeruginosa

The study explores the potential of repurposing finasteride, a drug commonly used for hair loss, as a quorum sensing inhibitor to combat Pseudomonas aeruginosa, a bacterium responsible for hospital-acquired infections. The research highlights the growing issue of antimicrobial resistance and the need for alternative treatments. Finasteride demonstrated significant anti-virulence activity by reducing biofilm formation by 45%, pyocyanin production by 49%, protease activity by 42%, and swarming motility by 39%. These findings suggest that finasteride could be a viable option for treating infections caused by Pseudomonas aeruginosa without directly targeting bacterial growth.