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Scientists have improved 3D models of human skin for research and medical uses, but still face challenges in perfectly replicating real skin.

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

Regenerative cosmetics can improve skin and hair by reducing wrinkles, healing wounds, and promoting hair growth.

Animal models, especially mice, are essential for advancing hair loss research and treatment.

Advanced human skin models improve drug development and could replace animal testing.

Prostaglandin E2 affects human platelet activity in complex ways that could lead to personalized heart disease treatments.

The document concludes that there is a significant lack of reporting on the sex and age of cells in skin research, which could affect clinical trials and treatments.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

The meeting focused on understanding, diagnosing, and finding treatments for irreversible hair loss diseases.

The C3H/HeJ mouse model is useful for studying and testing treatments for alopecia areata.

New treatments for hair loss are showing promise due to better understanding of genetics and the immune system.

High-content screening is useful for finding new treatments for rare diseases and has led to FDA-approved drugs.

Traditional and complementary medicine may help with skin conditions, but more high-quality research is needed.

The summit concluded that new treatments like Jak inhibitors show promise for Alopecia Areata and personalized approaches are needed.

The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.

Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.

More precise, personalized therapies are needed for autoimmune diseases.

3D bioprinting in plastic surgery could lead to personalized grafts and fewer complications.

Organoid technology is advancing and entering commercial use, with applications in disease modeling, drug development, and personalized medicine.

New synthetic polymers help improve skin wound healing and can be enhanced by adding natural materials and medicines.

Gene therapy shows promise for healing chronic wounds but needs more research to overcome challenges.

Hydrogels combined with extracellular vesicles and 3D bioprinting improve wound healing.

Mesenchymal stem cells show promise for effective skin repair and regeneration.

People with Alopecia Areata are more likely to have prediabetes and obesity.

The document concludes that computational methods using networks and various data can improve the process of finding new uses for existing drugs.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Women generally handle heart enlargement better than men, but it's riskier for them if it occurs; hormones like estrogen offer some protection.

Using special RNA to target a mutant gene fixed hair problems in mice.

Model improves accuracy in predicting hair loss effects.