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    Glossary Persistent Sexual Dysfunction

    long-lasting sexual issues after stopping certain medications

    Persistent Sexual Dysfunction refers to long-lasting sexual problems that continue even after stopping a medication or treatment that initially caused them. This can include issues like reduced libido, erectile dysfunction, or difficulty achieving orgasm. It is often associated with certain medications, such as antidepressants or finasteride, which is used for hair loss treatment.

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    1. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015 · 69 citations
    2. Persistent Sexual Dysfunction with Finasteride 1 mg Taken for Hair Loss Pharmacotherapy · 2016 · 19 citations
    3. Persistent sexual dysfunction and depression in finasteride users for male pattern hair loss: a serious concern or red herring? PubMed · 2014 · 10 citations
    4. An Old Problem with a New Cause-5 Alpha Reductase Inhibitors and Persistent Sexual Dysfunction The Journal of Sexual Medicine · 2011 · 9 citations
    5. PROSPECTIVE EVALUATION ON SEXUAL DYSFUNCTION PERSISTENCE, WORSENING OR IMPROVEMENT IN BPH PATIENTS AFTER FINASTERIDE OR DUTASTERIDE TREATMENT European Urology Supplements · 2008
    6. MP38-07 VASCULAR, NEUROLOGIC AND HORMONAL ABNORMALITIES IN MEN WITH PERSISTENT SEXUAL DYSFUNCTION AFTER DISCONTINUATION OF FINASTERIDE The Journal of Urology · 2022
    7. Faculty Opinions recommendation of Persistent sexual dysfunction and depression in finasteride users for male pattern hair loss: a serious concern or red herring? Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2015
    8. Insights into the peripheral nature of persistent sexual dysfunction associated with post-finasteride, post-SSRI and post-accutane syndromes: lessons learned from a case study International Urology and Nephrology · 2025
    9. 698 Clinical analysis in young patient with persistent sexual dysfunctions after finasteride assumption to prevent male pattern hair loss European Urology Supplements · 2012
    10. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2012 · 112 citations
    11. Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases International journal of risk & safety in medicine · 2018 · 54 citations
    12. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2013 · 3 citations
    13. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011 · 185 citations
    14. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014 · 81 citations
    15. Adverse Side Effects of 5α‐Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010 · 223 citations
    16. Letter to the Editor: “Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss” The Journal of Clinical Endocrinology and Metabolism · 2017 · 1 citations
    17. Faculty Opinions recommendation of Persistent sexual side effects of finasteride for male pattern hair loss. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2011
    18. Response to Letter: “Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss” The Journal of Clinical Endocrinology and Metabolism · 2017
    19. How routine pharmacovigilance failed to identify finasteride’s persistent sexual side effects International Journal of Andrology · 2021
    20. A proposed etiopathology of persistent dysfunctions emerging from use and discontinuation of 5-alpha reductase inhibitors: sequelae of drug-mediated microvasculopathy 2022
    21. Persistent Sexual and Nonsexual Adverse Effects of Finasteride in Younger Men Sexual medicine reviews · 2013 · 24 citations
    22. 5α-Reductase inhibitor therapy: Should physicians be concerned with persistent diminished libido, erectile dysfunction and depression in a subset of patients? Journal of Men's Health · 2010
    23. Young patients using finasteride exhibit risk of suicidality The Brown University Psychopharmacology Update · 2021
    24. Finasteride: suicidality or psychological adverse events Reactions Weekly · 2020
    25. POST-FINASTERIDE SYNDROME AND POST-SSRI SEXUAL DYSFUNCTION: TWO CLINICAL CONDITIONS APPARENTLY DISTANT, BUT VERY CLOSE Frontiers in Neuroendocrinology · 2023
    26. Post-Finasteride Syndrome – When will we Get the Courage to Fight the Dictating Pharma Industry – Despite Awareness of “Sexual, Neurological and Metabolic Side Effects in Young Men for Over a Decade” Archives of urology · 2020
    27. An (Ir)reversible Affection of the Sexual Sphere: A Case Report Journal of Psychosexual Health · 2026
    28. Persistent Sexual and Psychological Symptoms After Finasteride Discontinuation: A Cross-Sectional Observational Study Journal of Clinical Medicine · 2026
    29. Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin? Endocrine · 2018 · 40 citations
    30. Sexual Dysfunction Related to Drugs: a Critical Review. Part V: α-Blocker and 5-ARI Drugs Pharmacopsychiatry · 2015 · 15 citations