Insights Into the Peripheral Nature of Persistent Sexual Dysfunction Associated With Post-Finasteride, Post-SSRI, and Post-Accutane Syndromes: Lessons Learned From a Case Study

    February 2025 in “ International Urology and Nephrology ”
    Jackson Stachelek, Bernadette M. M. Zwaans, Roni M. Shtein, Kenneth M. Peters
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    TLDR Peripheral treatments showed some improvement in sexual dysfunction, but central symptoms remain challenging.
    This study investigates the peripheral nature of persistent sexual dysfunction associated with post-finasteride, post-SSRI, and post-accutane syndromes through a case study of three male patients. These patients underwent a 16-week treatment involving high-frequency electrical stimulation and low-intensity extracorporeal shock wave therapy. Results showed mild to moderate improvements in erectile function, penile sensitivity, and nocturnal erections. Peripheral neuropathy was identified in two patients, suggesting a treatable peripheral component to the syndrome. However, central symptoms persisted, indicating a need for further research to address the profound impact of these symptoms.
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