February 2025 in “International Journal of Cosmetic Science” This research studied European human hair, finding that cysteic acid and protein carbonylation increased with both chemical and photochemical oxidation. Protein carbonylation was highlighted as a more sensitive marker for photochemical oxidation, providing better in situ visualization of hair damage than cysteic acid.
August 2024 in “Applied Sciences” This review explored the causes of hair graying and evaluated how plant-derived extracts and phytochemicals might alleviate it, noting that certain compounds showed potential in enhancing melanocyte function, reducing oxidative stress, and influencing stress-related pathways based on experimental evidence.
April 2024 in “Journal of translational medicine” In this study, the researchers identified MJ04, a selective JAK3 inhibitor, as a promising candidate for promoting hair growth, demonstrating efficacy in both animal models and human hair follicle assays with a favorable safety and pharmacokinetic profile.
This study found that innate lymphoid cells-type 1 (ILC1) can induce alopecia areata by disrupting hair follicle immune privilege without the involvement of classical CD8+ T cells.
This study found that ILC1-like cells can induce alopecia areata symptoms in both ex vivo human hair follicles and in vivo mouse models, challenging the view that alopecia areata is solely CD8+ T cell-driven.
This study found that innate lymphoid cells-type 1 (ILC1lc) can induce alopecia areata (AA) by disrupting hair follicle immune privilege and causing hair follicle dystrophy and regression in both ex vivo and in vivo settings.
January 2001 in “China Surfactant Detergent & Cosmetics” This study compared the protective effects of two conditioners, Protective factor C and Keratin, on hair damaged by perm treatment using a model of damaged hair.
March 2016 in “The Korean Society of Beauty and Art” This study found that using a hair-hardener improved hair thickness, amino acid content, surface condition, tensile strength, and wave efficiency without causing any allergic reactions in participants.
April 2023 in “Han'gug miyong haghoeji/Journal of the Korean society of cosmetology” This study compared the effects of direct heat perms and softening heat perms on hair, analyzing damage and morphological changes to understand their impact on hair fibers and provide foundational data for future research.
20 citations
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January 2003 in “Journal of oleo science” This study found that both everyday physical and environmental stresses, as well as chemical treatments, contributed to hair damage, with cuticle layers being more noticeably affected.
18 citations
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July 2015 in “Journal of cosmetic dermatology” This study observed that combining hair dyeing with sodium hydroxide relaxers drastically increased protein loss in Caucasian virgin dark brown hair, while ammonium thioglycolate or guanidine hydroxide relaxers caused less damage.
6 citations
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October 2006 in “International Journal of Dermatology” This article discusses central trichoptilosis with onycholysis but provides no new clinical results.
3 citations
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August 2008 in “PubMed” This study found that digital perm treatments using sodium thioglycolate lotion led to the most significant reduction in protein content and greater hair damage compared to other methods and lotions.
3 citations
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June 2008 in “Springer eBooks” Hair care products clean, protect, style, color, and change hair structure.
1 citations
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January 2006 This study found that keratin fibers like human hair undergo thermal and mechanical transitions that can help assess changes from cosmetic processes such as bleaching and perm-waving.
January 2020 in “한국미용학회지” This study found that incorporating Musa extracts in pretreatment products effectively mitigated hair damage during permanent wave application, closely maintaining hair thickness and tensile strength compared to untreated hair.
May 2009 in “International Journal of Cosmetic Science” In this study, permanent waving treatments, especially those using lotion B and repeated procedures, were found to significantly damage hair protein content and physical properties.
This study found that, compared to oxidative treatments, reductive perm-waving more severely impacts the intermediate filaments in European human hair, while both treatments alter denaturation kinetics in a first-order manner.
Lightly perming scalp hair can lead to new hair growth, potentially treating baldness.
3 citations
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October 2006 in “Journal of dermatology” This study reported that X-ray microscopy provides more intact images of hair's internal structure compared to transmission electron microscopy, particularly for observing fine details like cuticle coarsening and cortex cracks.
1 citations
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April 2013 in “Pakistan Journal of Biological Sciences” This study found that hair coloring, waving, and ironing were associated with increased hair abnormalities compared to untreated hair in Iranian women.
1 citations
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February 1989 in “PubMed” In this study, human hair-carboxymethylated protein analysis showed that weathering for over 2.5 years can obscure electrophoretic patterns, while cosmetic treatments did not cause significant changes.
1 citations
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January 1988 This study found that hair treatments applied after chlorination, especially bleaching and dyeing, more significantly altered surface properties and weight loss, while perming most strongly affected tensile properties.
September 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study developed a biobased copolymer called SELP::KP, showing improved hair strength, elasticity, and conditioning properties while being a safer alternative to conventional chemical treatments, based on application to human hair in a laboratory setting.
This study found that a fermented mixture containing Sasa Borealis leaf improved tensile strength and glossiness in hair damaged by heat perm and dyeing, suggesting potential as a cosmetic ingredient.
January 2002 in “China Surfactant Detergent & Cosmetics” This study compared shampoos and found that shampoo D, containing polyquaternium-10, guar gum, and dimethicone, was most effective in restoring chemically permed hair.
3 citations
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July 2023 in “Acta Biomaterialia” This study demonstrates that a bioinspired peptide, PepACS, can efficiently and safely perm hair by interacting with keratin's sulfhydryl group without compromising tensile strength, and it shows potential for hair repair and dyeing applications in the hair care industry.
4 citations
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July 2022 in “The Journal of Clinical Endocrinology & Metabolism” This study identified a novel homozygous mutation in the 5'-UTR of the POMC gene, suggesting a new molecular mechanism for the syndrome of adrenal insufficiency, obesity, and red hair.
4 citations
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March 2007 in “Annales de Dermatologie et de Vénéréologie” This review discusses the adverse effects of hair care products, highlighting irritation dermatitis and allergic contact eczema due to common allergens like paraphenylenediamine and glycerol monothioglycolate, but reports no clinical results.
In this review of permanent hairstyles like perms, the authors discuss the chemical processes involved and highlight potential risks such as hair and scalp damage, emphasizing the need for careful client assessment and safe application techniques to mitigate these risks.