26 citations
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April 2012 in “PubMed” In this study, myofibroblasts in rat cutaneous fibrosis were characterized by expressions of vimentin, α-SMA, and Thy-1, and may derive from pericytes or perifollicular dermal sheath cells.
January 1997 in “The Showa University Journal of Medical Sciences” This study found that dihydrotestosterone significantly reduced the growth rate of perifollicular sheath cells but had no effect on nonfollicular fibroblasts or dermal papilla cells.
April 2026 in “Brazilian Journal of Hair Health” This narrative review highlights current insights into how perifollicular fibrosis contributes to androgenetic alopecia, by hindering hair regrowth and treatment response, and outlines potential antifibrotic therapies, though conclusive evidence from randomized controlled trials is still needed.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that electrical epilation in organ-cultured human scalp skin perturbs hair follicles by causing inflammation, impairing melanin production, and possibly inhibiting post-epilation hair re-growth.
30 citations
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October 1994 in “Journal of Cutaneous Pathology” This article describes a case of multiple perifollicular fibromas and suggests that cases previously reported as such might actually be instances of Birt‐Hogg‐Dubé syndrome.
42 citations
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June 2009 in “Journal of Cosmetic Dermatology” In this study, researchers observed that follicular microinflammation significantly contributes to the early stages of male androgenetic alopecia, potentially leading to perifollicular fibrosis and follicle destruction as the condition progresses.
1 citations
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January 2007 in “The Internet Journal of Dermatology” This case report describes a solitary nasal fibrofolliculoma in a 60-year-old male and reviews existing literature, indicating its rare occurrence and potential link with Birt-Hogg-Dube syndrome.
9 citations
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November 2004 in “SKINmed Dermatology for the Clinician” This case report describes a 54-year-old man diagnosed with fibrosing alopecia in a pattern distribution, presenting with follicular inflammatory lesions and scleroatrophy on the scalp.
January 2026 in “Open MIND” This upcoming review will investigate the role of hair follicle fibroblasts in androgenetic alopecia, focusing on their interactions with androgens and impact on cellular signaling and fibrosis.
This study found that dermoscopy combined with calcium fluorescent white staining effectively aided in the early diagnosis and treatment evaluation of tinea capitis by highlighting specific hair changes and fluorescent patterns associated with different dermatophyte infections in a sample of 20 patients.
October 2019 in “Skin appendage disorders” This study revisits and reproduces Felix Pinkus' concept of the vitreous membrane in hair follicles, suggesting these structures may play a role in differentiation or nutrition due to their location in metabolically dynamic regions.
19 citations
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November 1985 in “Archives of Dermatology” This case study documented a black male newborn developing large bullae that healed with hypopigmentation, suspecting proteolytic enzymes in keratinocytes caused the collagenolysis responsible for the condition.
90 citations
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June 2006 in “The American Journal of Dermatopathology” This review outlines the classification, histopathologic presentation, and pathogenetic concepts of scarring and nonscarring alopecias, reporting no new clinical results and emphasizing the need for clinicopathologic correlation.
46 citations
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January 1996 in “Journal of The American Academy of Dermatology” This study identified the presence of apoptotic or necrotic keratinocytes and hair shaft dystrophy as potential markers of hair loss in patients with HIV-1 infection.
29 citations
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September 2014 in “American Journal of Dermatopathology” This study found that horizontal sections of scalp biopsies in patients with Central Centrifugal Cicatricial Alopecia often reveal follicular miniaturization, inflammation, and scarring, which can guide personalized treatment.
1 citations
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July 2009 in “Journal of dermatology” This case report describes a 29-year-old Japanese man with follicular mucinosis, suggesting nestin-positive, multipotent hair follicle stem cells may be involved in reticular epithelial degeneration of the outer root sheath.
November 2025 in “Journal of Investigative Dermatology” Radiation-induced hair loss may be caused by hair growth stopping and inflammation in blood vessels.
September 2017 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This case report suggests that in African-American patients, the histology of Central Centrifugal Cicatricial Alopecia may resemble lichen planopilaris, indicating a potential diagnostic challenge.
February 2026 in “Nature Communications” This study combined spatial and single-cell transcriptomics to identify that hypercontractility of the connective tissue sheath activates PIEZO1 in hair follicles, leading to miniaturization in male androgenetic alopecia, and found that inhibiting this contraction improves hair growth in models.
July 2024 in “Iranian journal of pathology” This study described the clinicopathological features of patients with frontal fibrosing alopecia who underwent skin biopsies.
82 citations
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November 1985 in “Archives of Dermatology” This case report describes a black male newborn who developed bullae that healed with hypopigmentation, linked to collagenolysis and RER vacuoles potentially containing proteolytic enzymes.
4 citations
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September 2012 in “Journal of dermatological science” The hair follicle's connective tissue is a key source of a certain collagen in human scalp skin.
44 citations
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January 2006 in “Biological & Pharmaceutical Bulletin” This research suggests that testosterone-induced expression of TGF-beta1 and type I procollagen may lead to perifollicular fibrosis in androgenetic alopecia, with finasteride inhibiting this process as a possible mechanism for its effects.
37 citations
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November 2003 in “Veterinary pathology” This study showed that in C3H/HeJ mice, focal follicular inflammation starts before overt hair loss, with inflammation severity possibly reaching a threshold causing hair follicle dystrophy prior to visible hair loss.
17 citations
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January 2010 in “Acta Dermato Venereologica” This report details a case of a 43-year-old woman developing yellowish papular eruptions alongside typical acneiform skin reactions on her cheeks and chest following a switch from cetuximab to panitumumab treatment.
12 citations
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February 1999 in “British Journal of Dermatology” In this study, topical minoxidil was reported to increase fenestration in follicular capillary walls around anagen hair bulbs in male rats.
10 citations
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June 1998 in “International Journal of Dermatology” This article discusses inflammatory perifollicular fibrosis and alopecia but provides no new research findings.
30 citations
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May 2016 in “International Journal of Cosmetic Science” This study found that apoptosis was more prevalent in hair follicles of women with female pattern hair loss, particularly in miniaturized follicles, and was associated with follicular inflammation.
21 citations
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March 2019 in “Experimental Dermatology” This review discusses the role of perifollicular macrophages in hair growth and suggests targeting them could be relevant for managing hair growth disorders, but reports no new results.
6 citations
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September 2009 in “European journal of histochemistry” This study found that CD90+ stem cells with fibroblast-like morphology are present in the lower part of the anagen hair follicle in dogs.