January 2026 in “Clinical Cosmetic and Investigational Dermatology” This study found that targeting both hormonal and immune pathways improved treatment outcomes in androgenetic alopecia patients with an under-recognized inflammatory component called PIILIF, which may contribute to treatment resistance.
31 citations
,
December 2010 in “Journal of the American Academy of Dermatology” This study reports that structural abnormalities in the inner root sheath of hair follicles may cause the hair shaft to be loosely attached in patients with loose anagen hair syndrome.
23 citations
,
June 2012 in “Molecular Biology Reports” This study found that human outer root sheath cells express VEGF receptor-2, and exogenous VEGF165 significantly stimulates their proliferation through activation of the ERK signaling pathway.
April 2017 in “Journal of Investigative Dermatology” This study identified the dermal sheath as a key component of the hair follicle niche, essential for outer root sheath regression during the hair cycle, highlighting its importance in hair follicle support and regulation.
September 2017 in “Journal of Investigative Dermatology” This study found that intradermal injections of cultured autologous dermal sheath cup cells for androgenetic alopecia showed hair loss stabilization at 24 months without serious adverse effects and a sustained response in some participants.
12 citations
,
March 2018 in “Australasian Journal of Dermatology” This letter to the editor discusses the use of systemic minoxidil for loose anagen hair syndrome, noting a significant change in hair color, but reports no new study results.
7 citations
,
August 2018 in “The American Journal of Dermatopathology” This study describes a newly observed "inflammatory vellus involvement" pattern in early frontal fibrosing alopecia, which may lead to misdiagnosis due to the absence of typical histological features.
September 2017 in “Journal of Investigative Dermatology” This study found that infrared thermography might be a useful non-invasive tool to help diagnose frontal fibrosing alopecia by identifying active phases of the disease.
25 citations
,
July 2008 in “British Journal of Dermatology” This study observed dynamic changes in CD10 and CD34 expression in fetal and adult human hair follicles during embryogenesis and hair cycling.
21 citations
,
January 2019 in “Experimental dermatology” This review explores how low-energy He-Ne laser therapy may stimulate repigmentation in vitiligo by affecting mitochondrial pathways and melanocyte function, but does not report new clinical results.
520 citations
,
February 2001 in “Journal of Clinical Investigation” This study found that VEGF significantly enhances perifollicular vascularization during the hair growth phase, accelerating hair regrowth and increasing follicle and hair size, while its inhibition retards hair growth.
175 citations
,
December 2014 in “PLoS Biology” This study found that macrophages near hair follicles contribute to the activation of skin epithelial stem cells in mice, suggesting a novel role for macrophages in regulating hair growth.
63 citations
,
October 2011 in “Archives of Dermatology” Isolated long hairs at the original hairline can help diagnose Frontal Fibrosing Alopecia.
45 citations
,
June 2004 in “Lasers in Medical Science” This study found that non-coherent intense pulsed light (IPL) treatment significantly reduced hair growth by about 80% in patients with skin type III-V without causing side effects.
16 citations
,
October 2018 in “Biochemical and Biophysical Research Communications” In this study, sildenafil was found to enhance human dermal papilla cell proliferation and promote hair growth in mice, suggesting potential use in alopecia treatment.
13 citations
,
January 2019 in “Skin appendage disorders” This study reported that fibrosing alopecia in a pattern distribution can occur in patients of color, with clinical and histopathological features allowing for an accurate differential diagnosis.
11 citations
,
January 2013 in “Indian Dermatology Online Journal” This article reviews central centrifugal cicatricial alopecia, including its various forms and potential multifactorial causes, but provides no new clinical findings.
5 citations
,
February 2008 in “Experimental Dermatology” In this study, topical application of Cyclosporin A on mice skin induced hair growth by transitioning follicles from telogen to anagen, but no effect was observed on cultured human hair follicles.
Loose anagen hair syndrome in children may improve with age, but treatment results vary.
September 2023 in “Biomedicines” In this study, researchers found that subjects with clinical alopecia had significantly higher levels of squalene in their hair bulbs compared to controls, suggesting squalene as a potential metabolic and pathogenic marker for certain alopecia conditions.
June 2022 in “International journal of drug delivery technology” This study investigated the hair growth-promoting effect of topical nebivolol cream in mice, but the abstract does not provide specific results or conclusions.
July 2018 in “Elsevier eBooks” This study highlights lichen planopilaris as a form of scarring hair loss with symptoms like shedding and itching, and notes successful treatment options such as topical and oral antiinflammatory medications to preserve hair follicles by early intervention.
April 2012 in “Informa Healthcare eBooks” Syphilitic alopecia is a rare hair loss condition in secondary syphilis that looks similar to another condition but can be diagnosed with specific tests and responds to antibiotics.
30 citations
,
November 2013 in “Journal of The American Academy of Dermatology” This study reported that patterns of fibrosis identified through elastin staining may help distinguish specific forms of primary cicatricial alopecia in biopsy specimens, with certain patterns suggesting particular diagnoses.
April 2012 in “Informa Healthcare eBooks” Lichen planopilaris is a rare, chronic condition causing hair loss, mainly in middle-aged women, and early treatment is important to prevent permanent baldness.
January 2022 in “Stem cell biology and regenerative medicine” This review discusses the role of dermal sheath cells in hair follicle regeneration, suggesting they show potential for treating pattern hair loss, but emphasizes the need for further human studies.
207 citations
,
January 2011 in “Dermatologic Therapy” This article discusses the factors involved in optimizing laser hair removal, emphasizing patient selection, laser safety, and understanding laser–tissue interactions, but presents no new clinical findings.
158 citations
,
February 2000 in “Archives of dermatology” This study reports that some patients with androgenetic alopecia may also exhibit clinical and histological features of inflammation and fibrosis, similar to those found in lichen planopilaris.
122 citations
,
April 1995 in “Journal of Cutaneous Pathology” The document describes how to tell different types of non-scarring hair loss apart by looking at hair and scalp tissue under a microscope.
95 citations
,
January 2004 in “Archives of Dermatological Research” This study found that peripilar signs on the scalp are linked to perifollicular lymphocytic infiltrates in early androgenetic alopecia, detectable even in areas with high hair density.