Central Centrifugal Cicatricial Alopecia Presenting with Irregular Patchy Alopecia on the Lateral and Posterior Scalp

January 2015 in “ Skin appendage disorders ”

Mariya Miteva, Antonella Tosti

Central Centrifugal Cicatricial Alopecia CCCA patchy alopecia traction alopecia dermatoscopy pathology peripilar white-gray halos broken hairs follicular dropout perifollicular fibrosis inflammatory infiltrate

Studysummary This study identified a new variety of central centrifugal cicatricial alopecia that includes patchy hair loss on the lateral and posterior scalp in African-American women, which could be misdiagnosed as traction alopecia without dermatoscopy and pathology.

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The study identified a new clinical variety of Central Centrifugal Cicatricial Alopecia (CCCA) in 14 African-American women, characterized by patchy alopecia on the lateral and posterior scalp, in addition to the central scalp. Dermatoscopy and pathology were crucial in distinguishing this variety from traction alopecia, which was commonly associated in 10 patients. The findings emphasized the importance of these diagnostic tools to avoid misdiagnosis, revealing features such as peripilar white-gray halos, broken hairs, follicular dropout, perifollicular fibrosis, and mild inflammatory infiltrate.

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research Pathologic Diagnosis of Central Centrifugal Cicatricial Alopecia on Horizontal Sections

29 citations , September 2014 in “American Journal of Dermatopathology”

This study found that horizontal sections of scalp biopsies in patients with Central Centrifugal Cicatricial Alopecia often reveal follicular miniaturization, inflammation, and scarring, which can guide personalized treatment.

research Dermatoscopic Features of Central Centrifugal Cicatricial Alopecia

64 citations , June 2014 in “Journal of The American Academy of Dermatology”

This study found that a peripilar white gray halo around hair emergence is a highly specific and sensitive dermatoscopic feature for diagnosing central centrifugal cicatricial alopecia in African American patients with mild central thinning.

research Hair Breakage as a Presenting Sign of Early or Occult Central Centrifugal Cicatricial Alopecia

44 citations , September 2012 in “Archives of Dermatology”

This study observed that hair breakage may indicate early central centrifugal cicatricial alopecia in African American women, suggesting that it should be considered in their differential diagnosis.

research A Detective Look at Hair Biopsies from African-American Patients

40 citations , May 2012 in “British Journal of Dermatology”

This study reviewed scalp biopsies from African-American patients, identifying distinct features and diagnostic clues for scarring alopecia types such as traction alopecia and central centrifugal cicatricial alopecia.

research Hair and Scalp Dermatoscopy

245 citations , March 2012 in “Journal of The American Academy of Dermatology”

This review discusses the dermoscopic features of common hair and scalp disorders and reports no new clinical results, aiming to assist dermatologists in diagnosing conditions like tinea capitis and alopecia areata.

research Central Hair Loss in African American Women: Incidence and Potential Risk Factors

76 citations , November 2010 in “Journal of The American Academy of Dermatology”

In this study, a photographic scale and questionnaire revealed that extensive central scalp hair loss was observed in 5.6% of African American women, with an association to a history of tinea capitis.

research Determinants of Marginal Traction Alopecia in African Girls and Women

94 citations , September 2008 in “Journal of the American Academy of Dermatology”

This study found that traction alopecia risk was higher in adults than children and increased further when traction was combined with chemically relaxed hair.

research Central Scalp Alopecia Photographic Scale in African American Women

46 citations , July 2008 in “Dermatologic Therapy”

This study developed and evaluated a photographic scale to assess CCCA pattern and severity in African American women, finding it reproducible when used by investigators and participants.

research Hot Comb Alopecia

107 citations , September 1968 in “Archives of Dermatology”

In this study, researchers identified a form of irreversible scalp alopecia in Black women using hot combs, characterized by incomplete hair loss primarily on the crown and follicular scarring.

research Hot Comb Alopecia

112 citations , September 1968 in “PubMed”

In this study, irreversible alopecia on the crown of the scalp in Black women using hot combs was associated with chronic inflammation and follicle damage leading to scarring.