Central Centrifugal Cicatricial Alopecia Presenting with Irregular Patchy Alopecia on the Lateral and Posterior Scalp

January 2015 in “ Skin appendage disorders ”

Mariya Miteva, Antonella Tosti

Central Centrifugal Cicatricial Alopecia CCCA patchy alopecia traction alopecia dermatoscopy pathology peripilar white-gray halos broken hairs follicular dropout perifollicular fibrosis inflammatory infiltrate

TLDR The report found a new type of hair loss in African-American women that affects more areas of the scalp than previously thought.

The study identified a new clinical variety of Central Centrifugal Cicatricial Alopecia (CCCA) in 14 African-American women, characterized by patchy alopecia on the lateral and posterior scalp, in addition to the central scalp. Dermatoscopy and pathology were crucial in distinguishing this variety from traction alopecia, which was commonly associated in 10 patients. The findings emphasized the importance of these diagnostic tools to avoid misdiagnosis, revealing features such as peripilar white-gray halos, broken hairs, follicular dropout, perifollicular fibrosis, and mild inflammatory infiltrate.

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Research cited in this study

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research Pathologic Diagnosis of Central Centrifugal Cicatricial Alopecia on Horizontal Sections

29 citations, September 2014 in “American Journal of Dermatopathology”

Horizontal sections of scalp biopsies are good for diagnosing Central Centrifugal Cicatricial Alopecia and help customize treatment.

research Dermatoscopic Features of Central Centrifugal Cicatricial Alopecia

64 citations, June 2014 in “Journal of The American Academy of Dermatology”

Researchers found a white halo around hair in most patients with a specific type of hair loss, which helps in early diagnosis and treatment.

research Hair Breakage as a Presenting Sign of Early or Occult Central Centrifugal Cicatricial Alopecia

44 citations, September 2012 in “Archives of Dermatology”

Hair breakage may be an early sign of a hair loss condition called CCCA in African American women.

research A Detective Look at Hair Biopsies from African-American Patients

40 citations, May 2012 in “British Journal of Dermatology”

Recognizing specific features of African-American hair can help diagnose hair loss conditions.

research Hair and Scalp Dermatoscopy

245 citations, March 2012 in “Journal of The American Academy of Dermatology”

Dermatoscopy is useful for identifying different hair and scalp conditions and can reduce the need for biopsies.

research Central Hair Loss in African American Women: Incidence and Potential Risk Factors

76 citations, November 2010 in “Journal of The American Academy of Dermatology”

Some African American women's central scalp hair loss is linked to genetics and past fungal scalp infections, with more research needed on other causes.

research Determinants of Marginal Traction Alopecia in African Girls and Women

94 citations, September 2008 in “Journal of the American Academy of Dermatology”

Traction alopecia is more common in African women than girls, especially when traction is applied to chemically relaxed hair; avoiding such hairstyles may reduce the risk.

research Central Scalp Alopecia Photographic Scale in African American Women

46 citations, July 2008 in “Dermatologic Therapy”

A scale was made to measure hair loss severity in African American women.

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research Psoriatic Scarring Alopecia: A Case Report

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A woman with long-term scalp psoriasis developed rare scarring hair loss that didn't fully respond to treatments.