19 citations
,
June 2020 in “BMC Cancer” This study reported that genetic changes in trichilemmal carcinoma resemble those in other skin cancers, with TP53 mutations associated with aggressive clinical outcomes.
19 citations
,
November 2010 in “PubMed” This review discusses advancements in the genetic understanding of androgenic alopecia and the FDA-approved treatments, including a new laser hair comb, but reports no clinical results.
17 citations
,
July 1994 in “Journal of Dermatological Science” This article reviews the genetic and potential environmental factors in alopecia areata's pathogenesis and suggests a polygenic model but reports no new clinical findings.
15 citations
,
December 2017 in “Journal of The European Academy of Dermatology and Venereology” This letter discusses potential pathogenetic links among frontal fibrosing alopecia, androgenetic alopecia, and fibrosing alopecia in a pattern distribution and reports no new clinical findings.
13 citations
,
April 2022 in “Journal of Mind and Medical Sciences” This review discusses recent findings on the pathology, diagnosis, and treatment of inflammatory bowel disease and reports no new clinical results.
11 citations
,
July 2003 in “The Nurse practitioner” This article reviews diagnostic and management strategies for polycystic ovary syndrome in primary care and reports no new clinical results; it also discusses when specialist referral is appropriate.
10 citations
,
July 2022 in “Dermatology and Therapy” This review discusses the pathogenesis of melasma, including genetic, environmental, and hormonal factors, and highlights potential avenues for new treatments and preventive strategies, but reports no new experimental findings.
10 citations
,
May 1978 in “Acta Dermato Venereologica” In this study, seven patients with generalized toxic erythema developed sterile pustules localized to hair follicles or sweat ducts, with most having a history of medication, solvent exposure, or infection.
8 citations
,
March 2014 in “American Journal of Pathology” This study found that hairless mice with homozygous mutations developed significantly more aggressive basal cell carcinomas and a heightened inflammatory response to UVB exposure compared to their haired littermates.
8 citations
,
December 2020 in “The FASEB Journal” Blocking adenosine A2B receptor may prevent or treat hearing loss.
8 citations
,
May 1998 in “Journal of Oral and Maxillofacial Surgery” This article discusses the importance of oral and maxillofacial surgeons understanding the pathogenesis and treatment of acne vulgaris, but it presents no new research findings.
7 citations
,
March 2019 in “Frontiers in Cellular and Infection Microbiology” Understanding how our bodies interact with mosquito-borne viruses is crucial because there are few treatments and vaccines.
6 citations
,
July 2021 in “Bulletin of the National Research Centre/Bulletin of the National Research Center” This review discusses the transmission and immune response of SARS-CoV-2 and highlights ongoing research for developing vaccines and antiviral treatments, but it presents no new clinical findings.
5 citations
,
February 2022 in “Seminars in cell & developmental biology” This review discusses the complexities of hidradenitis suppurativa pathogenesis, highlighting issues with Notch signaling, immune dysregulation, and the role of keratinocytes and ECM, but reports no new clinical results.
4 citations
,
September 2018 in “Journal of Drug Delivery and Therapeutics” This article discusses the pathophysiology and treatment of polycystic ovary syndrome and reports no new results, emphasizing the higher risk of metabolic and cardiovascular issues for affected women.
3 citations
,
July 2023 in “International journal of molecular sciences” This review discusses the association between emotional stress-related neuropeptides and the pathogenesis of alopecia areata, reporting no new experimental findings.
3 citations
,
September 2021 in “BioEssays” This article discusses a novel hypothesis on the role of hair follicles in dandruff pathogenesis, focusing on immune response and inflammation due to scalp microbiota changes and sebum by-products, but reports no new clinical results.
2 citations
,
January 2023 in “Frontiers in Veterinary Science” This study found that although Stephanofilaria infection worsens buffalo fly lesion severity, other factors like bacterial infection and hypersensitivity to buffalo fly feeding also play significant roles.
1 citations
,
May 2023 in “Frontiers in endocrinology” The researchers reported that the novel MBTPS2 variant p.Glu172Asp found in a male proband is likely pathogenic, consistent with osteogenesis imperfecta symptoms and molecular signatures, including disrupted fatty acid metabolism and collagen production.
1 citations
,
April 2017 in “Journal of Investigative Dermatology” ZNF750 and MPZL3 are important in causing seborrheic dermatitis.
July 2025 in “Journal of Investigative Dermatology” Candida auris uses the immune response to colonize hair follicles.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This paper reviews recent advancements in understanding hair follicle structure and the role of JAKs in hair growth, though it does not report new experimental findings.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, researchers focused on the "bulge region" of hair follicles, identifying Janus kinases as key players in hair growth signaling, which could inform new therapies for hair restoration.
May 2026 in “Canadian Diabetes & Endocrinology Today” This review discusses the psychosocial impact and potential endocrine implications of androgenetic alopecia, particularly noting a moderate impairment in quality of life, but it reports no new clinical results.
April 2026 in “Russian Journal of Skin and Venereal Diseases” This review reports that hyperandrogenic conditions in women, which affect skin and overall well-being, lack dedicated treatment guidelines, presenting challenges in standardizing care.
January 2026 in “Immunity & Inflammation” This review discusses a "stochastic multi-hit model" to explain the onset, progression, and recurrence of vitiligo and other autoimmune skin diseases, emphasizing genetic and environmental influences, immune cell interactions, and unexplored mechanistic gaps.
January 2026 in “Dermatologic Therapy” This review highlights a disconnect between mechanistic insights and physiological relevance in preclinical models of hair loss disorders and suggests a shift toward more human-relevant systems could enhance translational research, despite limitations in existing models like transgenic mice and xenografts.
November 2025 in “Journal of Investigative Dermatology” Certain CD8+ T cells attack hair follicles in alopecia areata, suggesting they could be targeted for treatment.
November 2025 in “International Journal of Molecular Sciences” This review highlights various treatments for androgenetic alopecia that target its underlying pathophysiological mechanisms, reporting enhanced hair growth, especially when combining drugs, which shows improved outcomes over individual drug use alone.
This article hypothesizes that thymoma with aplastic anemia may result from abnormal autoimmune CD8+ T lymphocytes produced by the thymoma, potentially leading to other cytotoxic T-cell-mediated autoimmune diseases.