Does Complement Have a Role in the Pathogenesis of Alopecia Areata?

    January 2018 in “ Skin appendage disorders ”
    Margit Juhász, Natasha Atanaskova Mesinkovska
    TLDR The complement system might be involved in the development of alopecia areata and could lead to new treatments.
    The document investigated the role of the complement system in alopecia areata (AA). While early studies found no significant differences in complement levels between AA patients and healthy individuals, recent genetic research indicated that complement loci, like TRAF1/C5, might be linked to severe AA cases. Histological evidence on complement deposition at hair follicles was inconsistent. Understanding complement's role in AA could lead to new treatments, such as eculizumab, targeting C5.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 1000+ results

    Similar Research

    5 / 1000+ results
      Obstetric Dermatology

      research Obstetric Dermatology

      January 2009 in “Springer eBooks”
      The document concludes that managing skin conditions during pregnancy is important and requires specialized care.
      Alopecia and Thyroid Disease

      research Alopecia and Thyroid Disease

      January 2008 in “Springer eBooks”
      Thyroid disease can cause hair loss and treating thyroid problems might help with hair disorders.
      Vitiligo: A Comprehensive Overview

      research Vitiligo: A Comprehensive Overview

      532 citations, August 2011 in “Journal of the American Academy of Dermatology”
      Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.