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    GlossaryCell-Mediated Immunity (Cellular Immunity)

    immune response involving T cells targeting infected or abnormal cells

    Cell-Mediated Immunity (CMI) is a type of immune response that does not involve antibodies but instead relies on the activation of certain immune cells, particularly T cells, to fight off pathogens, infected cells, and cancer cells. This form of immunity is crucial for defending against intracellular pathogens, such as viruses and some bacteria, and plays a significant role in transplant rejection and autoimmune diseases.

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      learn Adenosine

      nucleoside used for hair regrowth stimulant properties
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      learn Tretinoin

      the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

      learn Melatonin

      hormone commonly taken for sleep aid has some topical benefits for hair

      learn Rapamycin

      mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

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      community Fats on your Head to Stop Hair Loss?

      in Research/Science  140 upvotes 11 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.
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      community Just found out I am Vitamin D deficient

      in Treatment  58 upvotes 3 years ago
      A user found out they are vitamin D deficient and was prescribed high-dose vitamin D supplements, asking if others had similar experiences and if it improved their hair. Some shared improved mood and testosterone levels after treatment, while another combined vitamin D supplements with finasteride due to family history of baldness.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  735 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community Does melatonin dissolve in isopropyl alcohol

      in Technology  7 upvotes 1 year ago
      The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.

      community My summation of PP405 - looks promising

      in Research/Science  194 upvotes 1 week ago
      PP405 shows promise for hair regrowth by manipulating stem cell characteristics and lactate dehydrogenase, with Phase 2a trials pending. Google Ventures' $15M investment suggests confidence, but results and market availability remain uncertain.