TLDR ADAM17 could be a potential target for treating PCOS.
This review explores the role of ADAM17 in the pathogenesis of polycystic ovary syndrome (PCOS), a common endocrinopathy in women of reproductive age characterized by chronic anovulation, insulin resistance, and increased cardiovascular risk. ADAM17, a metalloproteinase, is involved in various pathological processes, including inflammatory responses and ovarian dysfunction. The review highlights the lack of defined biomarkers for diagnosing gynecological disorders and the potential of ADAM17 as a target for therapeutic intervention in PCOS.
195 citations,
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