The Role of ADAM17 in PCOS Pathogenesis: A Review Paper

February 2024 in “ Journal of Health Science and Medical Therapy ”

Boren Preap, Kyung Taek Hong, Hao Lv, Jingfei Chen

ADAM17 polycystic ovary syndrome PCOS chronic anovulation insulin resistance metalloproteinase ovarian dysfunction endocrinopathy

TLDR ADAM17 could be a potential target for treating PCOS.

This review explores the role of ADAM17 in the pathogenesis of polycystic ovary syndrome (PCOS), a common endocrinopathy in women of reproductive age characterized by chronic anovulation, insulin resistance, and increased cardiovascular risk. ADAM17, a metalloproteinase, is involved in various pathological processes, including inflammatory responses and ovarian dysfunction. The review highlights the lack of defined biomarkers for diagnosing gynecological disorders and the potential of ADAM17 as a target for therapeutic intervention in PCOS.

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research Polycystic Ovarian Syndrome: Correlation Between Hyperandrogenism, Insulin Resistance, and Obesity

195 citations , November 2019 in “Clinica Chimica Acta”

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

research The Mechanism of Androgen Actions in PCOS Etiology

30 citations , August 2019 in “Medical Sciences”

Androgens play a key role in causing PCOS (Polycystic Ovary Syndrome).