The Role of ADAM17 in PCOS Pathogenesis: A Review Paper

February 2024 in “ Journal of Health Science and Medical Therapy ”

Boren Preap, Kyung Taek Hong, Hao Lv, Jingfei Chen

ADAM17 polycystic ovary syndrome PCOS chronic anovulation insulin resistance metalloproteinase ovarian dysfunction endocrinopathy

Studysummary This review discusses the role of ADAM 17 in gynecological disorders, particularly PCOS, and suggests its potential for therapeutic intervention, but reports no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.

This review explores the role of ADAM17 in the pathogenesis of polycystic ovary syndrome (PCOS), a common endocrinopathy in women of reproductive age characterized by chronic anovulation, insulin resistance, and increased cardiovascular risk. ADAM17, a metalloproteinase, is involved in various pathological processes, including inflammatory responses and ovarian dysfunction. The review highlights the lack of defined biomarkers for diagnosing gynecological disorders and the potential of ADAM17 as a target for therapeutic intervention in PCOS.

View this study on risetpress.com →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research Polycystic Ovarian Syndrome: Correlation Between Hyperandrogenism, Insulin Resistance, and Obesity

195 citations , November 2019 in “Clinica Chimica Acta”

This review discusses the interplay of hyperandrogenism, insulin resistance, obesity, and their role in polycystic ovary syndrome, but presents no new clinical results.

research The Mechanism of Androgen Actions in PCOS Etiology

30 citations , August 2019 in “Medical Sciences”

This review summarizes evidence suggesting that excess androgens play a key role in the origins of polycystic ovary syndrome, highlighting opportunities for developing targeted treatments.