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The document concludes that the development of certain tumors is influenced by genetic background and that a specific gene modification can lead to tumor regression and reduced growth.

The hedgehog signalling pathway is key in skin development and basal cell carcinoma, offering insights for prevention and treatment.

Using a gene therapy with the Sonic Hedgehog gene helps mice regrow hair faster after losing it from chemotherapy.

A woman with a new PTCH gene mutation has both Gorlin syndrome and severe hair loss.

The document is a detailed medical reference on skin and genetic disorders.

Activating the Sonic hedgehog gene in mice can start the hair growth phase.

Hair follicles offer promising targets for delivering drugs to treat hair and skin conditions.

New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.

The document concludes that permanent hair loss conditions are complex, require early specific treatments, and "secondary permanent alopecias" might be a more accurate term than "secondary cicatricial alopecia."

Transit-amplifying cells are crucial for tissue repair and can contribute to cancer when they malfunction.

Targeting ornithine decarboxylase can help prevent skin cancer.

Inhibiting ornithine decarboxylase may help prevent certain skin cancers.

The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.

The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.

Meis1 is crucial for skin health and tumor development.

The treatment was ineffective in humans.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

The document concludes that side effects from Smoothened inhibitor drugs for skin cancer are reversible and can be managed with a team approach to maintain quality of life.

The conclusion is that a certain test might help find cancer spread in lymph nodes for melanoma patients, but more research is needed due to false positives.

Cells treated with Wnt-10b can grow hair after being transplanted into mice.

The document says that treating the root cause of hair follicle damage is crucial to prevent permanent hair loss, and treatment options vary.

XIST RNA helps regenerate hair follicles by targeting miR-424 and activating hedgehog signaling.

The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.

Vitamin D and its receptor may help prevent skin cancer.

Vitamin D receptor may help protect against UV-induced skin cancer.

The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.

Ptch2 plays a key role in controlling stem cell function and the ability to regenerate after birth.