Tissue Engineering of the Reproductive System

    December 2010 in “ Elsevier eBooks ”
    Stefano Da Sacco, Laura Perin, Roger E. De Filippo
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    TLDR Cell transplantation faces challenges in genitourinary reconstruction, but alternative tissue sources and microencapsulation show promise.
    The document discussed the challenges and strategies in using cell transplantation for genitourinary reconstruction, particularly for urethral conditions requiring additional tissue. It highlighted the complications associated with using skin grafts, such as hair growth and graft shrinkage, and synthetic grafts, such as erosion and calcification. Alternative tissue sources included genital and extragenital skin flaps, bladder mucosal grafts, and buccal region grafts. Androgen replacement therapy was noted for its role in maintaining serum testosterone levels in hypogonadal states. The document also mentioned microencapsulation as an optimal immunoisolation technique, using polymers like calcium-alginate and poly(L-lysine) for therapeutic applications.
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