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Live imaging has advanced our understanding of stem cell behavior and raised new research questions.

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

Parathyroid hormones are important for hair growth, but their use in treating hair loss from chemotherapy is still uncertain.

Cell death shapes skin stem cell environments, affecting inflammation, repair, and cancer.

Hair follicle regeneration may slow tumor growth.

Muscles and nerves that cause goosebumps also help control hair growth.

The document concludes that the immune-inhibitory environment of the hair follicle may prevent melanoma development.

MicroRNAs are important for skin health and could be targets for new skin disorder treatments.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Hair follicles have a more inactive cell cycle than other skin cells, which may help develop targeted therapies for skin diseases and cancer.

A specific signal from hair cells controls the tightening of the surrounding muscle, which is necessary for hair shedding.

The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.

Skin cells show flexibility in healing wounds and forming tumors, with potential for treating hair disorders and chronic ulcers.

New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.

MicroRNAs play a crucial role in skin and hair health, affecting everything from growth to aging, and could potentially be used in treating skin diseases.

The document concludes that identifying the specific cells where skin cancers begin is important for creating better prevention, detection, and treatment methods.

Scientists have made progress in understanding hair follicle stem cells, identifying specific genes and markers, and suggesting their use in treating hair and skin conditions.

Vismodegib is effective for basal cell carcinoma but has severe side effects.

Multiphoton microscopy is a promising tool for detailed skin imaging and could improve patient care if its challenges are addressed.

Understanding and managing side effects of hedgehog pathway inhibitors can improve treatment for advanced basal cell carcinoma.

Cyclosporin A promotes hair cell growth and affects protein kinase C levels.

Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.

Runx genes are important for stem cell regulation and their roles in aging and disease need more research.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Stem cell therapy is promising for treating various health conditions, but more research is needed to understand its full potential and address challenges.

The document concludes that inherited epidermolysis bullosa is a challenging genetic condition requiring multidisciplinary care and new treatments.