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240-270 / 1000+ resultsresearch Facial Papules in a Patient With Lichen Planopilaris
This case report describes a woman with scalp lichen planopilaris who developed facial papules coinciding with her hair loss condition, raising the question of an associated diagnosis.
research Generation of Pax1/PAX1-Specific Monoclonal Antibodies
This study developed rat monoclonal antibodies that specifically detect Pax1/PAX1 protein, which could improve diagnostic protocols for conditions involving deregulated Pax1/PAX1 expression.
research ICP5249 Promotes Hair Growth by Activating the AMPK-Autophagy Signaling Pathway
This study investigated autophagy activator ICP5249 and found it promotes hair growth by enhancing cell proliferation and autophagy-related markers in human dermal papilla cells and hair follicles, with AMPKα playing a regulatory role, suggesting its potential as a hair growth ingredient.
research Proopiomelanocortin (POMC) and Psychodermatology
This review discusses the interplay between dermatology and psychology in psychodermatology, highlighting the impact of neuroendocrine stress pathways on skin diseases and the importance of considering skin of color.
research Characterization of Human KAP24.1, A Cuticular Hair Keratin-Associated Protein with Unusual Amino-Acid Composition and Repeat Structure
This study identified a novel keratin-associated protein, KAP24.1, which is specifically expressed in the human scalp and located in the hair cuticle.
research Identification of the sulfotransferase iso-enzyme primarily responsible for the bio-activation of topical minoxidil.
This abstract reports that topical minoxidil is currently the only FDA-approved treatment for pattern hair loss in both men and women.
research Effects of the Pineal Gland Upon the Hair Cycles in Mice
research Antibody-Capped Mesoporous Nanoscopic Materials: Design of a Probe for the Selective Chromo-Fluorogenic Detection of Finasteride
This study found that capped mesoporous silica nanoparticles conjugated with antibodies selectively released a dye when exposed to finasteride, with low detection limits and stable performance even after storage.
research Mechanisms and applications of the anti-inflammatory effects of photobiomodulation
This review discusses the effects of photobiomodulation, particularly its potential to reduce inflammation in various conditions, but it does not report new clinical findings.
research Melatonin induces a stimulatory action on the scrotal skin components of Soay ram in the non-breeding season
In this study, melatonin administration enhanced various cellular and structural features of the scrotal skin in Soay rams, including increased thickness, cell count, and gland activity.
research Red organic light-emitting diodes based photobiomodulation therapy enabling prominent hair growth
This study found that red OLED irradiation can significantly promote hair regrowth in mice, increasing hair length by 1.5 times and hair regrowth area by over 3 times after 20 days of treatment.
research Immunohistochemical expressions of mGluR5, P2Y2 receptor, PLC-?1, and IP3R-I and -II in Merkel cells in rat sinus hair follicles
research Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation
This study found that actively targeted AN2728-loaded nanocarriers reduced inflammation and improved skin condition in a mouse model of psoriasiform inflammation compared to free drug and non-targeted nanoparticles.
research Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective
This review examines melatonin's potential effects on human skin and hair follicle pigmentation, highlighting the need to confirm findings from cell cultures in physiological tissue contexts.
research Latanoprostene bunod ophthalmic solution 0.024% in the treatment of open-angle glaucoma: design, development, and place in therapy
This review summarizes clinical trials and comparative studies showing that latanoprostene bunod 0.024% is effective and safe for reducing intraocular pressure in patients with open-angle glaucoma or ocular hypertension, detailing its mechanism and side effects while considering its therapeutic role.
research The PER3 rs772027021 SNP induces pigmentation phenotypes of dyschromatosis universalis hereditaria
In this study, researchers found that a PER3 gene SNP may be pathogenic for a new subtype of dyschromatosis universalis hereditaria, especially when combined with a SASH1 mutation.
research Near Infrared (NIR) Light Therapy of Eye Diseases: A Review
This review highlights the potential of near-infrared light therapy to improve metabolic, antioxidant, and cognitive functions without adverse effects, and supports its use for visual and neurological conditions through molecular and cellular mechanisms, as reported in this source.
research 1410 Single-cell RNA sequencing reveals POUF51 and HES3 as regulators of the stem cell population in psoriasis
This research reexamined transcriptomic data to study stem and progenitor cell proliferation in psoriasis, finding that the number of committed progenitor cells increased eight-fold in psoriatic skin without altering stem cell numbers, potentially identifying new therapeutic targets.
research 328 The transcription factor CEBPB is a novel hub gene and multi-functional disease driver in Psoriatic skin inflammation
This study provides evidence that ILC1-like cells can induce alopecia areata in previously healthy human hair follicles, challenging the view that it is solely an autoantigen-dependent autoimmune disease.
research The prostamide‐related glaucoma therapy, bimatoprost, offers a novel approach for treating scalp alopecias
This study found that bimatoprost stimulated hair growth in both human scalp follicle cultures and mouse pelage in vivo, suggesting it might offer a promising treatment for scalp alopecias.
research Therapeutic targeting of ocular diseases with emphasis on PI3K/Akt, and OPRL pathways by Hedera helix L. saponins: a new approach for the treatment of Pseudomonas aeruginosa-induced bacterial keratitis
In this study, PEVIII, a nanocomposite chitosan-coated vesicle containing both α-hederin and hederacoside C, demonstrated notable antibacterial activity against Pseudomonas aeruginosa in a keratitis model, showing significant lesion reduction, tissue improvement, and decreased bacterial load and inflammatory markers compared to other treatments.
research Light-emitting diode photobiomodulation in dermatology: From professional systems to consumer devices — mechanisms, efficacy and safety
This review concluded that LED-based photobiomodulation is generally safe and effective for certain dermatologic conditions, though consumer devices often show less efficacy compared to professional systems.
research Characterization of Prostaglandin F2α Receptors in Human Eyelids
This study found that PGF 2α receptors were predominantly present in the inner root sheath of the bulb and stem of human eyelashes during the anagen phase.
research Photobiomodulation in Cells’ Repair
This review discusses the mechanisms, applications, and research evidence of photobiomodulation, highlighting its efficacy, safety, and potential for standardized evaluation methods, but reports no new clinical results.
research A prospective study of daylight photodynamic therapy for treatment of actinic keratoses in an Irish population
Daylight photodynamic therapy is effective and well-tolerated for treating actinic keratoses with minimal side effects.
research Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase
This study examined the structural and biochemical mechanisms of human lipocalin prostaglandin D synthase, detailing substrate and product binding processes at the catalytic site and suggesting potential for drug delivery targeting hydrophobic molecules.
research Effect of sinapic acid on hair growth promoting in human hair follicle dermal papilla cells via Akt activation
This study suggests that sinapic acid may promote hair growth in human hair follicle dermal papilla cells by activating specific signaling pathways and inducing the expression of growth factors.
research Frontal fibrosing alopecia associated with lichen planus pigmentosum
research Reverse Protein Engineering Of Firefly Luciferase
This study demonstrated that Reverse Protein Engineering can decrease the size of Firefly Luciferase from 550 to less than 80 amino acids, but further research is needed to ensure these smaller peptides retain bioluminescent activity.