Single-Cell RNA Sequencing Reveals POUF51 and HES3 as Regulators of the Stem Cell Population in Psoriasis

    April 2023 in “ Journal of Investigative Dermatology ”
    U. Eze, J. Cheng, R. Cho, R. Ghadially
    Image of study
    TLDR POUF51 and HES3 are key in controlling stem cell numbers in psoriasis.
    The study "1410 Single-cell RNA sequencing reveals POUF51 and HES3 as regulators of the stem cell population in psoriasis" reanalyzed previous scRNA sequencing data to understand the genes affecting stem cell (SC) and committed progenitor cell (CP) proliferation in psoriasis. The researchers focused on mitotic cell types and isolated four clusters corresponding to potential SCs and CPs. They found that the number of CPs increased eight-fold in psoriasis, with no detected change in the number of SCs in the basal layer. The study also identified genes highly expressed in specific mitotic psoriasis clusters, including POUF51 (upregulated in SCs), a regulator of stem cell maintenance, and HES1 (upregulated in CPs), a Notch target gene involved in keratinocyte asymmetric SC division. These findings could lead to new therapeutic targets for psoriasis skin manifestations in patients with mild to moderate disease.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 92 results

      community Got a microscope camera. Here’s the difference between healthy and miniaturized hair

      in Progress Pictures  492 upvotes 2 years ago
      A user who shared progress pictures of their scalp using a microscope camera, demonstrating the difference between healthy and miniaturized hair. Various explanations for the cause of this were discussed, such as DHT build-up in scalp sebum causing an autoimmune response leading to inflammation and eventual hair loss, with some suggesting a do-it-yourself treatment involving adding ascorbic acid powder to shampoo.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community C’est terrible - at my wits end

      in Female  449 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Please stop looking for a natural way to stop your hairloss

      in Chat  247 upvotes 2 years ago
      There is no natural way to stop hair loss; pharmaceuticals like minoxidil, finasteride, and RU58841 are the only effective treatments. Some users report success with minoxidil and microneedling, while others discuss the side effects of finasteride.

    Related Research

    1 / 1 results