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    Glossary p75 neurotrophin receptor

    protein on cell surfaces regulating survival and apoptosis

    The p75 neurotrophin receptor (p75NTR) is a protein found on the surface of certain cells, including neurons and hair follicle cells. It plays a crucial role in regulating cell survival, growth, and apoptosis (programmed cell death) by binding to neurotrophins, which are a family of proteins that promote the survival and function of neurons. This receptor is significant in both the development of the nervous system and in conditions like alopecia, where it can influence hair follicle health and regeneration.

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    Research 30 of 204

    1. A role for p75 neurotrophin receptor in the control of apoptosis‐driven hair follicle regression The FASEB Journal · 2000 · 96 citations
    2. p75 Neurotrophin Receptor Antagonist Retards Apoptosis-driven Hair Follicle Involution (Catagen) Journal of Investigative Dermatology · 2003 · 24 citations
    3. [Construction and identification of mouse model with conditional knockout of p75 neurotrophin receptor gene in epidermal cells by Cre-loxP system]. PubMed · 2019 · 1 citations
    4. ‘Neurotrophology’ of the hair follicle: neurotrophins act as auto‐ and paracrine growth factors and immunomodulators Experimental dermatology · 2006
    5. Differentiation of nestin-negative human hair follicle outer root sheath cells into neurons in vitro Molecular Medicine Reports · 2017 · 5 citations
    6. Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. PubMed · 1998 · 122 citations
    7. Inhibitory Effects of Polyacetylene Compounds from <i>Panax ginseng</i> on Neurotrophin Receptor-Mediated Hair Growth Biological & Pharmaceutical Bulletin · 2017 · 7 citations
    8. Expression patterns of the glial cell line–derived neurotrophic factor, neurturin, their cognate receptors GFRα-1, GFRα-2, and a common signal transduction element c-Ret in the human skin hair follicles Journal of The American Academy of Dermatology · 2008 · 18 citations
    9. Retardation of Hair Follicle Development by the Deletion of TrkC, High-Affinity Neurotrophin-3 Receptor Journal of Investigative Dermatology · 1999 · 14 citations
    10. Stress, Hair Growth Control, and the Neuro-Endocrine-Immune Connection Allergo Journal · 2000 · 7 citations
    11. Molecular biology of hair morphogenesis: Development and cycling Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution · 2003 · 155 citations
    12. Epithelial growth control by neurotrophins: leads and lessons from the hair follicle Progress in brain research · 2004 · 99 citations
    13. Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition Journal of Molecular Medicine · 2005 · 76 citations
    14. Touch Receptors Undergo Rapid Remodeling in Healthy Skin Cell Reports · 2016 · 31 citations
    15. Neural Mechanisms of Hair Growth Control Journal of Investigative Dermatology Symposium Proceedings · 1997 · 101 citations
    16. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007 · 159 citations
    17. Macrophages as central mediators of sympathetic neuro-immune interplay in autoimmunity Frontiers in Immunology · 2025
    18. A Hot New Twist to Hair Biology ˜The œAmerican journal of pathology (Print) · 2005 · 174 citations
    19. Regeneration of skin appendages and nerves: current status and further challenges Journal of Translational Medicine · 2020 · 71 citations
    20. Symposium Proceedings of the 4th Intercontinental Meeting of Hair Research Societies: “The World of Hair 2004” Journal of Investigative Dermatology Symposium Proceedings · 2005
    21. DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization International journal of molecular sciences · 2016 · 22 citations
    22. Diversification and Specialization of Touch Receptors in Skin Cold Spring Harbor perspectives in medicine · 2014 · 81 citations
    23. Nerve growth factor and burn wound healing: Update of molecular interactions with skin cells Burns · 2023 · 11 citations
    24. KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin Development · 2009 · 82 citations
    25. GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells npj regenerative medicine · 2020 · 7 citations
    26. Reawakening GDNF's regenerative past in mice and humans Regenerative Therapy · 2022 · 1 citations
    27. Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation EMBO journal · 2003 · 65 citations
    28. 4-Aminopyridine Induces Nerve Growth Factor to Improve Skin Wound Healing and Tissue Regeneration Biomedicines · 2022
    29. Neurogenic Inflammation in Stress-Induced Termination of Murine Hair Growth Is Promoted by Nerve Growth Factor American Journal of Pathology · 2004 · 108 citations
    30. Promoting axonal regeneration through exosomes: An update of recent findings on exosomal PTEN and mTOR modifiers Brain Research Bulletin · 2018 · 14 citations