Sex Hormones Modulate Pathogenic Processes in Experimental Traumatic Brain Injury

    February 2019 in “ Journal of neurochemistry ”
    Christina Gölz, F. Kirchhoff, Jana Westerhorstmann … Michael K. E. Schäfer
    Studysummary This study found that pharmacological inhibition of sex steroid synthesis impacts pathogenic processes in traumatic brain injury in a sex-specific manner, with distinct effects of letrozole and finasteride on molecular and neurological outcomes.
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    Research cited in this study 7

    1. Neurosteroids in Adult Hippocampus of Male and Female Rodents: Biosynthesis and Actions of Sex Steroids Frontiers in endocrinology · 2018
    2. The 5α-Reductase Inhibitor Finasteride Exerts Neuroprotection Against Ischemic Brain Injury in Aged Male Rats Translational Stroke Research · 2018
    3. Finasteride Inhibited Brain Dopaminergic System and Open-Field Behaviors in Adolescent Male Rats CNS Neuroscience & Therapeutics · 2017
    4. 5-Alpha-Reductase Inhibitors and Combination Therapy Urologic Clinics of North America · 2016
    5. Finasteride Improves Motor, EEG, and Cellular Changes in Rat Brain in Thioacetamide-Induced Hepatic Encephalopathy American Journal of Physiology-gastrointestinal and Liver Physiology · 2014
    6. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    7. Age-Related Changes in Brain and Pituitary 5α-Reductase with Finasteride (Proscar) Treatment Neurobiology of Aging · 1995