Differentiation of Nestin-Negative Human Hair Follicle Outer Root Sheath Cells Into Neurons In Vitro

    January 2017 in “ Molecular Medicine Reports ”
    Wei Wu, Xiaoli Wu, Ying Ji, Zhen Gao
    Studysummary This study found that nestin-negative hair follicle stem cells can differentiate into neural stem cell-like cells, but not mature neurons, through a multi-step neuro-induction process.
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    Research cited in this study 6

    1. Isolation of Multipotent Nestin-Expressing Stem Cells Derived from the Epidermis of Elderly Humans and TAT-VHL Peptide-Mediated Neuronal Differentiation of These Cells International Journal of Molecular Sciences · 2013
    2. Human Hair Follicle Pluripotent Stem Cells Promote Regeneration of Peripheral Nerve Injury: An Advantageous Alternative to ES and iPS Cells Journal of Cellular Biochemistry · 2009
    3. Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles American Journal Of Pathology · 2006
    4. Implanted Hair Follicle Stem Cells Form Schwann Cells That Support Repair of Severed Peripheral Nerves Proceedings of the National Academy of Sciences · 2005
    5. Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons Proceedings of the National Academy of Sciences · 2005
    6. Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells Proceedings of the National Academy of Sciences · 2004

    Related research 1

    1. Hair Follicle Stem Cell Marker Nestin Expression in Regenerating Hair Follicles of Patients with Alopecia Areata European Journal of Dermatology · 2011