September 2024 in “Journal of Cosmetic Dermatology” In this study, researchers found that Ectoin, derived from halophilic bacteria, can mitigate stress-related skin damage by reducing cortisone's inhibitory effects on essential skin proteins and decreasing UVB-induced glucocorticoid activity, highlighting its potential as a preventative agent for stress-induced skin issues.
April 2019 in “Journal of Investigative Dermatology” This study found that bioelectric and biochemical signaling mechanisms coordinate collective cell movement during chicken feather bud morphogenesis, suggesting a potential new angle for research in skin development and wound healing.
January 2006 in “Heilongjiang yiyao kexue” This study found that children with repetitive respiratory tract infections had significantly lower levels of the trace elements zinc, iron, and copper in their hair compared to healthy children.
2 citations
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July 2005 in “International Joint Conference on Artificial Intelligence” This study suggests that EREG, released from ORS cells, may promote hair growth by activating specific receptors and modulating ROS generation, offering a potential new treatment for hair loss.
March 2023 in “Frontiers in Cell and Developmental Biology” This review covers the role of proteoglycans in tissue growth and regeneration and highlights several studies on their potential as therapeutic targets, but reports no new clinical results.
11 citations
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November 2009 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” This study found that bolandiol increased lean body mass and bone mineral density in castrate adult male rats, exhibiting tissue selectivity and acting through multiple receptor pathways with less potency compared to other androgens.
1 citations
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September 2022 in “Journal of dermatological science” This study found that a combination of vitamins in hair care products promoted hair shaft elongation in a mouse model by activating the PlGF/VEGFR-1 signaling pathway.
2 citations
,
January 2025 in “Development” In this study, researchers explored ear pinna development in two rodent species and identified that BMP5 plays a crucial role in chondroblast proliferation but not in their initial specification, with implications for understanding tissue differentiation and potential impacts on reconstructive surgery.
7 citations
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April 1996 in “British Journal of Dermatology” This study found that intermediate filaments and matrix proteins in presumptive hair shaft cells are synthesized sequentially, identifying a new polypeptide component that changes during hair cell differentiation.
January 2019 in “CLINICAL AND EXPERIMENTAL MORPHOLOGY” 108 citations
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April 2004 in “Medicinal Research Reviews” This review discusses the medicinal chemistry of steroid sulfatase inhibitors for estrogen- and androgen-dependent disorders but reports no new clinical results.
43 citations
,
January 2016 in “Cellular physiology and biochemistry” This study reports that EGF at specific concentrations promotes the proliferation and migration of hair follicle ORS cells by activating the Wnt/β-catenin signaling pathway in vitro.
40 citations
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March 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study visualized mitochondrial metabolism in cultured bovine hair follicles and plucked human hairs, finding that ROS and mitochondrial polarization correlate in specific hair follicle regions, particularly near keratin deposition sites.
9 citations
,
August 2021 in “Biomedicines” This study found that 17β-estradiol was the most powerful hormone for inducing APE1/Ref-1 secretion in cultured vascular endothelial cells, with secretion occurring through exosomes dependent on estrogen receptors and intracellular calcium.
27 citations
,
December 2005 in “Journal of Cutaneous Pathology” This study found that while malignant pilomatricomas maintain some keratin expression patterns seen in benign counterparts, they notably express additional epithelial keratins, potentially influencing tumor calcification.
14 citations
,
February 2020 in “Scientific reports” This study found that telocytes in human scalp tissue were located around hair follicles and glands and may be involved in skin regeneration and homeostasis.
April 2018 in “Journal of Investigative Dermatology” This study found that ERBB2 mutations and amplifications are likely key drivers of extramammary Paget disease, suggesting potential for targeted therapies and cancer immunotherapy due to the moderately high mutational load observed.
This study found that super-enhancers in squamous cell carcinoma stem cells are distinctly different from those in normal skin stem cells, with ETS2 playing a crucial role in promoting tumor growth.
July 2025 in “Underline Science Inc.” This study examined how reactive oxygen species influence cell wall biomechanics in Arabidopsis thaliana root hairs, providing insights essential for understanding plant growth, stress responses, and potential agricultural applications.
9 citations
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October 1995 in “Clinical Dysmorphology” This study described a Scottish family with hidrotic ectodermal dysplasia featuring variable symptoms such as hypo/oligodontia, thin hair, and heat tolerance, and concluded they exhibited overlapping traits with Clouston syndrome.
5 citations
,
January 2000
161 citations
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August 2013 in “Journal of experimental botany” This study found that specific ATP-competitive TOR inhibitors (asTORis) decrease root growth in Arabidopsis thaliana in a dose-dependent manner, similar to their effects on mammalian cells.
73 citations
,
January 2016 in “International review of cell and molecular biology” Cornification evolved from keratinization in vertebrates, with differences between mammals and sauropsids.
80 citations
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June 2002 in “Molecular Biology of the Cell” This study found that type II keratins in proliferating epithelial tissues are phosphorylated at a conserved motif during mitosis and stress, impacting keratin solubilization and reorganization.
86 citations
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April 2009 in “Journal of anatomy” This paper reviews the evolution of skin appendages and keratin-associated proteins among amniotes, proposing a model for their genetic divergence without new experimental results.
August 2024 in “Journal of Cosmetic Dermatology” This study investigates differences in nutritional status, vitamin, and mineral levels between individuals with telogen effluvium and a control group, aiming to understand the nutritional factors involved in this condition.
2 citations
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June 2024 in “Heliyon” This study identified 1965 different metabolites in various tissues of *Oresitrophe rupifraga* Bunge using a targeted metabolomics approach and found significant metabolic differences between its aboveground and underground parts, providing insights into the plant's unique growth traits and potential cultivation and utilization.
September 2001 in “PubMed” This study developed a non-destructive X-ray fluorescence technique to quantitatively analyze elemental content in human hair and constructed a database of element concentrations in healthy Swedish, Caucasian individuals.
100 citations
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November 2017 in “EMBO Reports” This review discusses the roles of metabolism, reactive oxygen species, intracellular pH, and cell morphology in influencing cell fate decisions during stem cell differentiation but reports no new experimental results.
26 citations
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May 1991 in “Clinical and experimental dermatology” In this study, oral etretinate resulted in increased hair length and loss of beading in a childhood monilethrix case, while the scalp's keratosis pilaris persisted.