TLDR Hair structural proteins are synthesized sequentially in specific cells, offering a new way to study hair proteins and defects.
The study investigated the synthesis locations of hair structural proteins in human anagen follicles by microdissecting live tissue containing presumptive hair shaft (PHS) cells. Using protein solubilization and polyacrylamide gel electrophoresis, researchers compared keratin proteins in hair and PHS. They found that intermediate filaments (IF) and matrix proteins were synthesized sequentially in PHS. A previously unobserved polypeptide component was identified, which varied in proportion as PHS cells differentiated. The study highlighted PHS as an alternative source for studying human hair proteins, offering a new basis for examining hair defects and comparing hair proteins in different contexts.
135 citations
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198 citations
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2 citations
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7 citations
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April 1996 in “British Journal of Dermatology” Hair structural proteins are synthesized sequentially in specific cells, offering a new way to study hair proteins and defects.
385 citations
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