291 citations,
April 2010 in “Gastroenterology” Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.
208 citations,
December 2003 in “Journal of Investigative Dermatology” Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.
194 citations,
May 2000 in “Journal of Investigative Dermatology” The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.
159 citations,
July 2006 in “Endocrine Reviews” Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
140 citations,
August 2011 in “Biomaterials” Keratose, derived from human hair, is a non-toxic biomaterial good for tissue regeneration and integrates well with body tissues.
112 citations,
January 2014 in “Molecular and cellular therapies” Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.
80 citations,
April 2011 in “Plant physiology” White lupin uses specific genes to grow root hairs and access phosphorus when it's scarce.
39 citations,
July 2021 in “Stem Cell Research & Therapy” Using fat stem cells and blood cell-rich plasma together improves healing in diabetic wounds by affecting cell signaling.
39 citations,
January 2019 in “Cells” Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.
35 citations,
February 2019 in “Cell Communication and Signaling” BMP6 and Wnt10b control whether hair follicles are resting or growing.
30 citations,
March 2017 in “ACS biomaterials science & engineering” Hair follicles are valuable for regenerative medicine and wound healing.
30 citations,
June 2014 in “Seminars in Immunology” Future research on ectodysplasin should explore its role in diseases, stem cells, and evolution, and continue developing treatments for genetic disorders like hypohidrotic ectodermal dysplasia.
25 citations,
December 2018 in “Human Molecular Genetics” The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.
21 citations,
December 2016 in “PLOS ONE” Scientists made skin stem cells from other human cells with over 97% efficiency, which could help treat skin conditions.
18 citations,
December 2020 in “Frontiers in cell and developmental biology” miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.
13 citations,
January 2022 in “Stem cell reviews and reports” Mouse stem cells from hair follicles can improve wound healing and reduce scarring.
12 citations,
August 2020 in “Frontiers in Genetics” H19 boosts hair growth potential by activating Wnt signaling, possibly helping treat hair loss.
8 citations,
January 2017 in “Elsevier eBooks” Certain nutrients can help keep skin healthy as we age.
7 citations,
August 2020 in “Animal biotechnology” A specific RNA in cashmere goats helps improve hair growth by interacting with certain molecules.
7 citations,
January 2019 in “Pharmaceutical Biology” Eclipta prostrata helps hair growth and maintains the growth phase by affecting certain growth factors.
4 citations,
November 2022 in “Acta dermato-venereologica” People with hidradenitis suppurativa often have lower vitamin D levels, weaker hip bones, and altered bone metabolism markers.
4 citations,
January 2019 in “International journal of molecular sciences” Genetically modified sheep with more β-catenin grew more wool without changing the wool's length or thickness.
2 citations,
December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” miR-29 is a key factor that accelerates aging.
2 citations,
November 2022 in “Animal Bioscience” A specific RNA modification in cashmere goats helps activate hair growth-related stem cells.
1 citations,
January 2024 in “Theranostics” Exosomes show promise for future tissue regeneration.
1 citations,
January 2018 in “Recent clinical techniques, results, and research in wounds” Using developmental signaling pathways could improve adult wound healing by mimicking scarless embryonic healing.
1 citations,
May 2017 in “InTech eBooks” Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.
1 citations,
October 2015 in “CRC Press eBooks” Nutricosmetics with active ingredients can help with hair loss and improve hair growth.
April 2024 in “Research Square (Research Square)” MSC-protein helps regenerate gum tissue and bone.
January 2024 in “Journal of applied biological chemistry” Glehnia littoralis and Andrographis paniculata extracts can significantly boost hair growth.