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Human enzymes can detoxify harmful substances but might also increase their cancer risk.

The enzyme PST is found in developing human kidneys and helps with detoxification and development.

Cyproterone acetate may cause liver cancer at high doses, but is considered safe at recommended doses for approved uses.

Minoxidil works in liver and outer hair root sheath for hair growth.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

The dog's skin condition improved after removing a tumor that was causing hormone imbalances.

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

Progestogens are essential in menopausal hormone therapy to prevent uterine cancer and must be chosen carefully based on individual needs.

Sulfotransferase SULT1A1 activity may predict minoxidil treatment success for hair loss.

Minoxidil breakdown varies by enzymes, affecting hair loss treatment effectiveness.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Scientists identified three genes important for processing certain brain chemicals, thyroid hormones, and medications.

Men and women experience skin aging differently due to changes in sex hormone levels with age.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Rare adrenal cancers that secrete androgens or estrogens have a poor prognosis and are treated primarily with surgery.

Environmental factors and exposure to toxins may contribute to male infertility by affecting sperm and hormone function.

Androgen replacement therapy can improve libido and mood in women with severe androgen deficiency, but more research is needed on its long-term safety.

Estrogens and progesterone are key in regulating melasma pigmentation.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Cytokines and neuropeptides are key in controlling androgen levels, affecting skin and hair conditions.

Common Black hair care products may affect hormone levels and potentially impact health, especially in reproductive and metabolic areas.

The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.