Combined Oral Contraceptives Promote Androgen Receptor And Estrogen Receptor Alpha Upregulation In The Female Prostate (Skene’s Paraurethral Glands) Of Adult Gerbils (Meriones Unguiculatus)
January 2018
in “
Reproduction, Fertility and Development
”
cyproterone acetate ethinyloestradiol androgen receptor oestrogen receptor alpha epithelial atrophy glandular hyperplasia cell proliferation prostatic lesions prostatic intraepithelial neoplasia cell degeneration antiandrogenic effects oestrogenic activity vagina urethra MGMT immunoreactivity DNA repair prostatic disorders CPA EE AR ERα
Studysummary This study concluded that cyproterone acetate alone produced antiandrogenic effects on the female gerbil prostate, while ethinyloestradiol alone stimulated estrogenic activity, and their combination led to prostatic lesions.
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