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Glossary Estrogen Receptor Alpha

protein inside cells that binds to estrogen hormone

Estrogen Receptor Alpha (ERα) is a protein found inside cells that binds to the hormone estrogen. This receptor is crucial for regulating various biological processes, including reproductive functions and the development of certain tissues. In the context of hair and alopecia, ERα can influence hair growth and loss, as estrogen plays a role in the hair growth cycle.

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Research

5 / 1000+ results

research The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action of Estrogen via Estrogen Receptor Beta?

65 citations , May 2006 in “Journal of Investigative Dermatology”

This study found that dexamethasone significantly reduced ERα mRNA levels and increased aromatase mRNA and activity in cultured human hair follicle dermal papilla cells, suggesting a glucocorticoid-dependent mechanism for estradiol action.

Combined Oral Contraceptives Promote Androgen Receptor And Estrogen Receptor Alpha Upregulation In The Female Prostate (Skene’s Paraurethral Glands) Of Adult Gerbils (Meriones Unguiculatus)

research Combined oral contraceptives promote androgen receptor and oestrogen receptor alpha upregulation in the female prostate (Skene’s paraurethral glands) of adult gerbils (Meriones unguiculatus)

3 citations , January 2018 in “Reproduction, Fertility and Development”

This study concluded that cyproterone acetate alone produced antiandrogenic effects on the female gerbil prostate, while ethinyloestradiol alone stimulated estrogenic activity, and their combination led to prostatic lesions.

research Minoxidil May be a Partial Agonist of Estrogen Receptor Alpha

April 2026 in “microPublication”

In this study, researchers explored whether minoxidil, a common treatment for androgenetic alopecia, may have estrogenic activity and found preliminary evidence suggesting it could act as a partial agonist of Estrogen Receptor α (ERα).

research Reproduction of the human relevant potency threshold (HRPT) for estrogen receptor alpha agonism in an inference performance screen for ICCVAM’s regulatory scientific confidence framework

October 2025 in “Frontiers in Toxicology”

This study found that a human relevant potency threshold for estrogen receptor alpha agonism may serve as a health-protective screening tool, and highlights inference performance as essential for scientific confidence frameworks.

research Ferulic acid promotes hair growth via estrogen receptor alpha activation in cultured human dermal papilla cells

March 2026 in “Scientific Reports”

This study found that Cnidium officinale extract and its compound ferulic acid improved hair growth by promoting dermal papilla cell function and mitochondrial activity, suggesting their potential as a new treatment option for alopecia, possibly through estrogen receptor alpha activation.

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community Theaflavin (Black Tea Extract) reduce DHT, androgen receptor activity and estrogen

6 upvotes 3 years ago

Theaflavin, a black tea extract, may inhibit DHT and androgen receptor activity, but its effectiveness for hair loss is debated. Users report no significant improvement with theaflavin, while some find beta sitosterol helpful.

community Alternatives/unorthodox hairloss protocols to the big three

in Chat 1 upvotes 7 months ago

The conversation discusses alternative and unorthodox hair loss treatments, including RU58841, nandrolone, and dianabol, as well as theoretical approaches involving high doses of estrogen and selective estrogen receptor modulators. These methods are considered extreme and potentially harmful but are explored for those unable to tolerate traditional 5-alpha reductase inhibitors.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Is the combination of spironolactone and estrogen more or less effective than finasteride?

4 upvotes 4 years ago

Spironolactone and estrogen may be more effective for hair regrowth in transgender women than finasteride alone. Estrogen and spironolactone suppress testosterone, potentially reducing DHT more effectively than finasteride.

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learn Overview

learn Estradiol

an estrogen promoting hair regrowth more commonly used in women

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