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Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

Hair and wool have complex microscopic structures with microfibrils and varying cystine content.

Scientists found a new, less invasive way to study body clocks using hair cells, which shows shift workers' body clocks don't match their lifestyles.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

JAK inhibitors help with skin conditions but need more research on dosing and safety.

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

Applying a special compound can promote hair growth without harmful side effects.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.

Circadian rhythms are crucial for stem cell function and tissue repair, and understanding them may improve aging and regeneration treatments.

Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.

Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.

Wnt10b overexpression can regenerate hair follicles, possibly helping treat hair loss and alopecia.

A20 protein is crucial for normal skin and hair development.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

TRH stimulates human hair growth and extends the hair growth phase.

Androgens slow hair growth by altering Wnt signaling in balding cells.

Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Wnt signaling may be linked to heart diseases in aging and could be a target for future treatments.

Androgens like testosterone affect hair growth and oil production differently across body parts and individuals.

Men with male-pattern baldness have more androgen receptors in their scalp's oil glands, which may contribute to hair loss.