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Megestrol acetate helps fat-derived stem cells grow, move, and turn into fat cells through a specific receptor.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

Androgen self-administration might be controlled by membrane receptors, not nuclear ones.

Finasteride, a drug used for certain conditions, can cause serious side effects like sexual dysfunction, suicidal thoughts, and increased diabetes risk, and there's a need for more awareness and research about these effects.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

The document concludes that managing skin conditions during pregnancy is important and requires specialized care.

Environmental factors and chemicals might affect hormone balance and contribute to common hair loss.

Krt15+ cells in the mouse intestine resist radiation and can start tumors.

Hair follicle studies suggest that maintaining telomere length could help treat hair loss and graying, but it's uncertain if mouse results apply to humans.

MicroRNAs could be key biomarkers and therapeutic targets for PCOS.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Dihydrotestosterone makes arteries stiffer in female mice by reducing estrogen receptor expression.

Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.

Both estrogens and androgens are important for health in both males and females.

Melasma's causes include genetics, sun exposure, hormones, and oxidative stress, and understanding these can help create better treatments.

A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.

Genetics and hormones play a role in male and female hair loss, but more research is needed to fully understand it.

Nitric Oxide has potential in medicine, especially for infections and heart treatments, but its short life and delivery challenges limit its use.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.

We need better ways to test and understand SARMs to make safer and more effective treatments.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.