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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The study found that sweat glands contain different types of stem cells that help with healing and maintaining healthy skin.

New nanofiber technology improves wound healing by supporting cell growth and delivering treatments directly to the wound.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Growing human skin cells in a 3D environment can stimulate new hair growth.

Apoptosis is essential for human skin development and forming a functional epidermis.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

Understanding where cancer cells come from helps create better prevention and treatment methods.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Some medicinal plants can help heal wounds and may lead to new treatments.

Stem cell self-renewal is complex and needs more research for full understanding.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

Turmeric may have benefits for skin health, but more research is needed to confirm its effectiveness.