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The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Melanocytes are crucial for skin pigmentation and can affect conditions like melanoma, vitiligo, and albinism, as well as hair color and hearing.

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

MicroRNAs are important for skin health and could be targets for new skin disorder treatments.

Activating NRF2 might help treat hair disorders by improving antioxidant defenses.

The skin and thymus develop similarly to protect and support immunity.

Ozone therapy might improve cancer treatment and reduce its side effects.

Stem cell differentiation is crucial for skin barrier maintenance and its disruption can lead to skin diseases.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

P-cadherin is important for hair growth and health, and its problems can cause hair and skin disorders.

Sex hormones, especially estradiol, can change chicken feather shapes and colors.

The research found that a complex gene network, controlled by microRNAs, is important for hair growth in cashmere goats.

Rac1 is essential for proper hair structure and color.

The research identified genes that explain why some sheep have curly wool and others have straight wool.

Melanocytes are important for skin and hair color and protect the skin from UV damage.

AGA, a common hair loss, is caused by genetics, hormones, age, and environmental factors.

Different types of fibroblasts play specific roles in wound healing and cancer, which could help improve treatments.

Melatonin affects certain genes and pathways involved in cashmere goat hair growth.

Melatonin can increase cashmere yield by altering gene expression and restarting the growth cycle early.

Researchers found that certain RNA sequences play a role in yak hair growth and these sequences are somewhat similar to those in cashmere goats.

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

Different types of skin cells play specific roles in development, healing, and cancer.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.

MicroRNAs are crucial for controlling skin development and healing by regulating genes.