95 citations,
July 2010 in “Genes & development” Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.
72 citations,
April 2008 in “Organogenesis” Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.
59 citations,
September 2015 in “Journal of Immunology” Certain proteins, caspases-1 and -11, are important in the early development of skin inflammation in mice.
51 citations,
June 2021 in “Signal Transduction and Targeted Therapy” The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.
48 citations,
July 2008 in “Acta Biochimica et Biophysica Sinica” Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.
47 citations,
December 2019 in “Frontiers in immunology” A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.
40 citations,
November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” S100A3 protein is crucial for hair shaft formation in mice.
39 citations,
January 2013 in “Journal of Investigative Dermatology” Changing Wnt signaling can lead to more or less hair growth and might help treat hair loss and skin conditions.
38 citations,
September 2012 in “Biochemical and biophysical research communications” Human leukocytes and beard hair follicle cells have internal daily clocks, and PER1 and PER3 genes may indicate individual circadian rhythms.
35 citations,
May 2022 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism” Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.
34 citations,
April 2014 in “Psychopharmacology” Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.
25 citations,
January 2021 in “Journal of drugs in dermatology” Sonidegib and vismodegib are similarly effective for advanced basal cell carcinoma, but sonidegib might have a slightly better safety profile.
25 citations,
November 2016 in “Progress in Biophysics & Molecular Biology” R-spondins and their receptors help increase bone growth and may be used to treat bone loss diseases.
23 citations,
May 2016 in “American Journal of Pathology” The research suggests that a specific skin gene can be controlled by signals within and between cells and is wrongly activated in certain skin diseases.
22 citations,
November 2012 in “Journal of cosmetic dermatology” Stem cells can rejuvenate skin, restore hair, and aid in wound healing.
22 citations,
October 2012 in “Cell Transplantation” Cells treated with Wnt-10b can grow hair after being transplanted into mice.
18 citations,
September 2015 in “Biochemical and Biophysical Research Communications” XEDAR triggers a specific signaling pathway in cells.
17 citations,
October 2017 in “British Journal of Dermatology” The article concludes that hair loss is a common side effect of drugs treating skin cancer by blocking the hedgehog pathway, but treatment should continue, and more selective drugs might prevent this side effect.
16 citations,
July 2016 in “International Journal of Medical Sciences” Wnt5a slows down hair growth by blocking a specific pathway during hair regeneration.
11 citations,
September 2020 in “OncoTargets and Therapy” Dihydrotestosterone increases growth and spread of human brain cancer cells, and blocking its formation might help treat this cancer.
11 citations,
October 2014 in “Gene” The S250C variant in a gene may cause autoimmunity and immunodeficiency by impairing protein function.
9 citations,
February 2022 in “Nature communications” Rare changes in the KRT82 gene are linked to a higher risk of Alopecia Areata.
8 citations,
May 2019 in “Journal of dermatological treatment” Vismodegib is effective for basal cell carcinoma but has severe side effects.
8 citations,
February 2017 in “Experimental dermatology” Hair follicles may help teach the immune system to tolerate new self-antigens, but this can sometimes cause hair loss.
5 citations,
October 2010 in “Cancer Prevention Research” The research suggests new treatments for skin cancer could target specific cell growth pathways.
4 citations,
April 2021 in “Plant journal” OsUEV1B protein is essential for controlling phosphate levels in rice.
4 citations,
March 2021 in “Journal of Dermatology” Impaired autophagy may cause hair loss by triggering early catagen.
1 citations,
August 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” A new mutation in the TMEM173 gene and a risk allele in IFIH1 cause a unique set of immune-related symptoms.
April 2024 in “Frontiers in pharmacology” Cynoglossum amabile has medicinal potential but poses safety concerns due to liver toxicity.
Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.