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Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.

ePUKs could be valuable for regenerative medicine due to their wound healing abilities.

In vivo lineage labelling is better than in vitro methods for identifying and understanding stem cells.

Skin cells and certain hair follicle areas produce hemoglobin, which may help protect against oxidative stress like UV damage.

PTEN helps control the number and health of skin stem cells by working with the protein BMAL1.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.

Stem cell differentiation is crucial for skin barrier maintenance and its disruption can lead to skin diseases.

Small molecule IM boosts hair growth by changing stem cell metabolism.

Different types of skin stem cells can change and adapt, which is important for developing new treatments.

Primary care is key in managing PCOS, focusing on lifestyle changes and medications like birth control and metformin.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Fat cells are important for tissue repair and stem cell support in various body parts.

Eating less can slow aging and help keep stem cells healthy by cleaning out damaged cell parts.

Lymphatic vessels are essential for health and can be targeted to treat various diseases.

Fat tissue stem cells show promise for repairing different body tissues and are being tested in clinical trials.

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.