The Skin Mycobiome and Intermicrobial Interactions in the Cutaneous Niche

    September 2023 in “ Current opinion in microbiology ”
    Meret Tuor, Salomé LeibundGut‐Landmann
    Image of study
    TLDR Certain fungi protect skin health, but changes can allow harmful fungi to cause serious infections, needing more research for treatment and control.
    The document discusses the skin mycobiome, primarily dominated by the fungus Malassezia, which may act as a skin guardian by outcompeting other fungi. However, changes in skin conditions can lead to the displacement of Malassezia by the fungal pathogen Candida auris, potentially causing fatal infections. The interplay between Malassezia and other skin microbes contributes to skin health and disease. C. auris can form robust biofilms and colonize skin, especially in individuals with poor health, advanced age, and thinner skin. The document also highlights the potential antagonistic relationship between Malassezia and C. auris, influenced by the host immune system. The World Health Organization emphasizes the need for improved surveillance and research against fungal pathogens like C. auris due to their serious health risks. The document concludes by stressing the need for future studies to understand the complex interplay between these fungi, the host, and other skin microbes, which could lead to the development of mycobiome-based therapeutic approaches for skin disorders and control of fungal pathogens.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community How uninformed the general public is about hair loss

      in Chat  318 upvotes 10 months ago
      The conversation highlights the general public's lack of knowledge about hair loss, with various ineffective remedies suggested, such as not wearing hats or using hair fibers. The only effective treatments mentioned for male pattern baldness are medications like minoxidil and finasteride, and hair transplants.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Scalp, eyebrow, eyelash and pubic hair loss.

       6 upvotes 6 years ago
      The user experienced significant hair loss on the scalp, eyebrows, eyelashes, and pubic area, along with itchy, flaky skin and red patches. They have a history of eczema and dermatitis and suspect that stopping shampoo use and taking Ritalin may have contributed to the issue.

      community My Experience and a Discourse on "DUPA"

      in Treatment  9 upvotes 6 months ago
      The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

      community Should I be hopeful? Oral min 5mg dutasteride 1mg

      in Is this regrowth?  22 upvotes 8 months ago
      The conversation discusses hair loss treatments including oral minoxidil 5mg, dutasteride 1mg, and suggestions to use a derma stamp on the scalp. Some users believe these treatments can improve hair condition or at least stabilize loss, while one suggests considering a hair transplant after a year if desired.

      community Diffuse thinning fucking sucks

      in Update  430 upvotes 10 months ago
      The conversation discusses various treatments for hair loss, including finasteride, minoxidil, dutasteride, microneedling, and checking for nutrient deficiencies. Some users suggest adding hydrocortisone butyrate, low-dose progesterone, or tretinoin to treatment regimens, while others recommend cosmetic solutions like Toppik hair fibers or shaving the head.

    Similar Research

    5 / 1000+ results