research REVIEW OF SO-CALLED ASEPTIC NEUTROPHILIC DERMATOSES
The review says skin conditions with sterile pustules need more research for better treatments.
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research Erosive pustular dermatosis of the scalp: A neutrophilic folliculitis within the spectrum of neutrophilic dermatoses
This study concluded that erosive pustular dermatosis of the scalp may be a type of spongiotic, pustular superficial folliculitis, sharing similarities with other neutrophilic dermatoses.
research Sterile neutrophilic dermatitis in a cat - a case report
This case report details a cat with sterile neutrophilic dermatitis that improved with cessation of previous medications and local povidone iodine therapy.
research Human umbilical cord mesenchymal stem cell therapy for atopic dermatitis through inhibition of neutrophil chemotaxis
In this study, human umbilical cord mesenchymal stem cells and their conditioned medium significantly improved symptoms in mouse models of atopic dermatitis, potentially through exosome-dependent pathways, suggesting a cell-free therapeutic strategy.
research Author response: Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis
This study found that skin-infiltrating neutrophils play a crucial role in triggering chronic itch in atopic dermatitis by promoting skin hyperinnervation and enhanced expression of itch signaling molecules in a mouse model.
research Decision letter: Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis
This study found that neutrophils are crucial for initiating chronic itch in atopic dermatitis and suggest that targeting neutrophils may help alleviate symptoms in this condition.
research The crosstalk of monocyte-neutrophil in hair follicles regulates neutrophil transepidermal migration in contact dermatitis
In this study, researchers used a murine model of irritant contact dermatitis to reveal that hair follicle regions serve as key sites for neutrophil transepidermal migration, which requires MMP-9 expression stimulated by dermal monocytes.
research 1113 Targeting anti-inflammatory immunonanocarriers to human and murine neutrophils via Ly6 antigen for psoriasiform dermatitis alleviation
This study found that NIMP-R14-conjugated nanoparticles, loaded with roflumilast, effectively targeted neutrophils to reduce inflammation and improve symptoms in a mouse model of psoriasiform dermatitis, suggesting potential for targeted therapy in autoimmune skin diseases.
research 178 Neutrophil elastase is critical in linear IgA bullous dermatosis in mice
In this study, a mouse model of scarring alopecia demonstrated significantly reduced CD200R expression in affected skin, which may contribute to immune attacks on hair follicles.
research Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis
This review discusses how ionizing radiation causes skin damage by inducing cellular senescence in keratinocytes, which secrete inflammatory mediators, recruiting immune cells and exacerbating inflammation, impacting the skin barrier function and healing.
research Topical Application of Aprepitant Inhibits Erlotinib-induced Facial Dermatitis/Hair Loss
In this study, researchers found that applying topical aprepitant, which blocks substance P receptors, significantly reduced facial dermatitis and hair loss in rats experiencing erlotinib-induced skin side effects, highlighting the neurogenic inflammation's role and the protective effect of ROS inhibition.
research Erosive pustular dermatosis of the scalp and multiple sclerosis: just a coincidence?
This case study describes a 23-year-old woman with erosive pustular dermatosis of the scalp who later developed multiple sclerosis, suggesting a possible shared immunological etiology involving neutrophil hyperactivation.
research Chronic Erosions and Alopecia: A Case of Erosive Pustular Dermatosis of the Scalp in an Elderly Male
This article reports a case of erosive pustular dermatosis on the scalp of an elderly male, highlighting its complex diagnosis and successful treatment with high-potency topical corticosteroids.
research Epidermal growth factor receptor inhibitor Geftinib-induced erosive pustular dermatosis of the scalp – A report with a brief review of the literature
In this case report, a 65-year-old woman with non-small cell lung cancer experienced scarring alopecia with papulo-pustular lesions on the scalp due to gefitinib treatment, marking it as a rare instance of gefitinib-induced erosive pustular dermatosis of the scalp.
research Erosive pustular dermatosis of the scalp: a pathogenetic мystery and therapeutic challenge
This report details a case of a 58-year-old male diagnosed with erosive pustular dermatosis of the scalp, which improved following 3-5 weeks of treatment with topical clobetasol proprionate.
research Incidence and haemato-biochemical alterations in dermatoses associated with hypothyroidism in dogs
This study reports that dogs with dermatoses linked to hypothyroidism displayed a significant incidence of specific haematological and biochemical alterations, such as elevated cholesterol and triglyceride levels and reduced thyroid hormones, compared to healthy dogs, with Labrador Retrievers showing the highest breed predisposition.
research Distinguishing histopathologic features of acantholytic dermatoses and the pattern of acantholytic hypergranulosis
This study found that adnexal acantholysis does not reliably distinguish pemphigus vulgaris from pemphigus foliaceus, but the level of acantholysis and degree of dyskeratosis serve as distinguishing features among acantholytic disorders.
research Sterile suppurative folliculitis associated with acute myeloblastic leukaemia
This case study suggests a possible rare follicular variant of neutrophilic dermatosis linked to myelogenous leukemia, where skin lesions improved following chemotherapy treatment.
research Scattered Skin Eruptions in a Patient With Inflammatory Bowel Disease
This report discusses a case of vesiculopustular eruption in a patient with ulcerative colitis, highlighting the effective use of ustekinumab for treatment and suggesting its consideration in similar cases of IBD-related skin lesions.
research Pyodermatitis vegetans associated with multiple myeloma
A skin condition called pyodermatitis vegetans was found in a patient with multiple myeloma for the first time.
research JAMA Dermatology—The Year in Review, 2021
In 2021, JAMA Dermatology published significant findings on skin conditions post-COVID vaccination, melanoma surveillance, atopic dermatitis treatments, and confirmed that sun protection does not harm bone health.
research The many faces of interleukin-17 in inflammatory skin diseases
This article reviews the role of IL-17 in inflammatory skin disorders and highlights its potential therapeutic targeting in both neutrophilic and lymphocyte-mediated conditions, reporting no new experimental results.
research Pustules
This article discusses the clinical characteristics of pustular skin conditions and reports no new results, highlighting that not all pustular dermatoses are caused by infections.
research Atypical pediatric presentation of alopecic and aseptic nodules of the scalp with features of dissecting cellulitis
This case report describes a 9-year-old boy with atypical alopecic and aseptic nodules of the scalp, suggesting possible inclusion within the spectrum of typical AANS and DCS due to its prepubertal onset and facial involvement.
research Evidence of a Causal Relationship Between Body Mass Index and Immune-Mediated and Inflammatory Skin Diseases and Biomarkers: A Mendelian Randomization Study
This Mendelian randomization study suggests a causal link between higher BMI and increased risk of psoriasis, atopic dermatitis, and hidradenitis suppurativa, potentially due to elevated biomarkers such as triglycerides and C-reactive protein.
research Scalp Pustule as a Manifestation of Erlotinib-Induced Skin Toxicity: Report of Two Cases and Literature Review
This study reports two cases of erlotinib-induced erosive pustular dermatosis of the scalp in patients with non-small cell lung cancer, emphasizing the need for dermatological monitoring during EGFR inhibitor therapy.
research Nonpruritic urticaria – a sign of serious systemic disease
This case report identifies a 51-year-old woman whose nonpruritic urticated rash was an initial presentation of systemic lupus erythematosus, highlighting the importance of comprehensive serological evaluation and biopsy for accurate diagnosis.
research Diagnosis and Management of Primary Cicatricial Alopecia: Part II
This review examines the clinical features, histology, and treatment options for various neutrophilic and mixed primary cicatricial alopecias, but presents no new data.
research Scarring Alopecia
This article discusses primary cicatricial alopecia, highlighting the need for early and precise diagnosis to effectively manage and treat these complex inflammatory hair disorders, but presents no new clinical results.
research Dissecting Cellulitis of the Scalp
This study underscores the importance of using trichoscopy and histopathology for the differential diagnosis of primary neutrophilic cicatricial alopecias to facilitate early intervention and prevent cicatricial alopecia progression.