Skin Manifestations Associated With Systemic Diseases – Part I

    September 2021 in “ Anais Brasileiros de Dermatologia
    Ana Luisa Sampaio, Aline Lopes Bressan, Bárbara Nader Vasconcelos, Alexandre Carlos Gripp
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    Studysummary This article reviews how skin manifestations can aid in diagnosing various systemic diseases, focusing primarily on their association with rheumatologic conditions while also addressing vascular, granulomatous, and other disease impacts, aiming to provide dermatologists with practical diagnostic insights.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The document provides a comprehensive review of skin manifestations associated with systemic diseases, focusing on conditions like Lupus Erythematosus (LE), Dermatomyositis (DM), Rheumatoid Arthritis (RA), and various granulomatous diseases. In LE, skin lesions can range from benign to severe, sometimes fatal eruptions. DM is an inflammatory disease with various cutaneous manifestations, and its skin lesions' clinical course may not parallel that of muscle disease. RA is an autoimmune disease associated with inflammation and joint deformities, with lesions suggestive of the disease. The document also discusses conditions like palisaded granulomatous dermatitis, Felty’s syndrome, Still’s disease, Raynaud’s phenomenon, Sjogren’s syndrome, scleroderma, and Sweet’s syndrome, each with their unique skin manifestations. Other conditions like Behçet’s disease, Bowel-associated dermatosis-arthritis syndrome (BADAS), Pyoderma gangrenosum, Erythema elevatum diutinum, and various forms of vasculitis are also covered. The document emphasizes the importance of early diagnosis to minimize potential complications.
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