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New genes and pathways are important for testosterone production and male sexual development.

New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.

European guidelines recommend regular eye and ear exams, skin care, vitamin D supplements, and cautious use of medications for managing congenital ichthyoses.

Hair follicle stem cells are a promising source for tissue repair and treating skin or hair diseases.

Dermatologists play a key role in treating skin symptoms of PCOS like dark patches, excess hair, acne, and hair loss.

Applying a specific inhibitor lightens skin and hair color.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

SHBG may be a useful early indicator and treatment target for PCOS.

The extracellular matrix is crucial for controlling skin stem cell behavior and health.

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

Excessive hair growth in women often has no known cause and is not linked to race or other hormonal symptoms.

Certain drugs that block specific enzymes can help treat prostate diseases.

Botox increased hair count in men with baldness and might work by improving scalp blood flow.

Polycystic Ovary Syndrome is common but often undiagnosed, and early treatment is important to prevent health problems.

Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.

Surface-modified nanoparticles mainly use non-follicular pathways to enhance skin permeation of ibuprofen and could improve treatment for inflammatory skin diseases.

Some natural compounds can protect fish ear cells from damage by certain antibiotics without affecting the antibiotics' ability to fight infections.

Advancements in creating skin grafts with biomaterials and stem cells are promising, but more research is needed for clinical application.

Surface Plasmon Resonance is a useful tool for studying protein interactions and has potential for future technological advancements.

Azathioprine's effectiveness and safety require careful monitoring and more research, especially regarding its use with corticosteroids and the role of TPMT status in patients.

Fetal cells could improve skin repair with minimal scarring and are a potential ready-to-use solution for tissue engineering.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

RADA16 is a promising material for tissue repair and regenerative medicine but needs improvement in strength and cost.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Endo-HSE helps grow hair-like structures from human skin cells in the lab.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

The conclusion is that exogen is a unique hair cycle phase and the new sampling method specifically targets this stage, which may help in future hair loss research.

FOXN1 gene mutations cause a rare, severe immune disease treatable with cell or tissue transplants.

Skin organoids are a promising new model for studying human skin development and testing treatments.