Cutaneous Manifestations in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy: A Comprehensive Review

    January 2024 in “ Biomedicines ”
    Florica Șandru, Răzvan Petca, Mihai Cristian Dumitraşcu, Aida Petca, Ana-Maria Ionescu, Livia-Cristiana Băicoianu-Nițescu
    TLDR The review shows that skin symptoms like chronic fungal infections, hair loss, and skin depigmentation are key for early detection and management of APECED.
    The review on Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED) highlights the significant cutaneous manifestations, including chronic mucocutaneous candidiasis (CMC), alopecia areata (AA), and vitiligo, with varying prevalence rates across different populations. It emphasizes the importance of early detection and comprehensive monitoring of these symptoms for better patient care. The review also discusses the genetic underpinnings, particularly mutations in the AIRE gene, and the role of IL-17-mediated immunity in the pathogenesis of APECED. The presence of autoantibodies against type I interferons and Th17-associated cytokines is noted as a significant diagnostic marker. The review calls for further research to understand the genotype-phenotype relationship and improve patient care, highlighting the need for a multidisciplinary approach due to the complex interplay between endocrine and dermatological symptoms.
    Discuss this study in the Community →

    Research cited in this study

    10 / 10 results

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Seeking Advice: Unusual Hair Loss at 31 Years Old - Any Insights? (M)

      in Chat  15 upvotes 8 months ago
      A 31-year-old man who previously had good results with minoxidil, finasteride, and nizoral for hair loss is now experiencing unusual hair loss and side effects from finasteride. Respondents suggest it might be severe retrograde alopecia and recommend exploring other treatment options due to his inability to tolerate finasteride.

      community C’est terrible - at my wits end

      in Female  445 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community TE turned into Scarring hairloss

      in Update  12 upvotes 9 months ago
      The user experienced hair loss due to a crash diet and later developed scarring hair loss. They are now on finasteride, oral minoxidil, LDN, Zyrtec, and Oztela to reduce scalp inflammation and promote hair regrowth.

    Related Research

    1 / 1 results