10 citations
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August 2024 in “Clinical Cosmetic and Investigational Dermatology” This review reports that natural compounds show promise in slowing skin photoaging by targeting cellular pathways in keratinocytes and fibroblasts. However, comprehensive clinical studies are needed to verify their efficacy and safety.
November 2024 in “Journal of Cosmetic Dermatology” This study found that a hair serum with plant-derived ingredients significantly reduced hair loss in women with chronic telogen effluvium over 16 weeks, and was well-tolerated, leading to improved hair characteristics and quality of life compared to a control group.
February 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review evaluates the efficacy and safety of natural hair growth actives set to enter the 2025–2026 market, noting their potential as alternatives to conventional therapies for alopecia but highlighting formulation challenges that may impact their effectiveness.
February 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review critically evaluated natural hair growth actives for the 2025–2026 marketplace and found they show potential as alternatives to conventional therapies for androgenetic alopecia, with favorable safety and patient acceptance, though challenges such as formulation instability and limited follicular penetration remain.
July 2026 in “Journal of Investigative Dermatology” This study in mice found that using modified illite as a carrier for topical minoxidil enabled effective delivery without the solvent toxicity typically associated with minoxidil, while the illite also promoted hair growth through anti-inflammatory and pro-proliferative mechanisms.
12 citations
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October 2007 in “PubMed” This study reports that keratin actives may protect various hair types from chemical damage, restore damaged fibers' mechanical strength, and reduce color fading.
December 2025 in “Pharmaceuticals” This study found that a natural illite-based carrier could deliver minoxidil topically with preserved efficacy, minimizing solvent toxicity, and showed hair-growth-promoting activity via anti-inflammatory and pro-proliferative mechanisms in mice.
April 2024 in “The journal of phytopharmacology” This study found that extracts from orchid calluses can stimulate hair follicle growth and enhance the proliferation of hair follicle stem cells in vitro, suggesting potential applications in sustainable hair care products using natural bioactive compounds.
39 citations
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September 2016 in “Expert Opinion on Drug Delivery” This review explores how colloidal drug delivery systems can enhance the stability, absorption, and bioavailability of phytochemicals, potentially rediscovering ancient compounds' therapeutic benefits and overcoming limitations like poor solubility and bioavailability.
1 citations
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May 2019 in “Frontiers in Pharmacology” The book provides detailed information on natural ingredients in beauty products and emphasizes the need for more human trials to confirm their effectiveness.
10 citations
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August 2024 in “ACS Omega” This review discusses the use of nanomaterials in cosmetics, highlighting their benefits like enhanced stability and skin penetration, while also noting potential health risks and the role of natural ingredients in formulations.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This research suggests that antifungal hair serums, incorporating essential oils and herbal extracts, may offer a promising alternative for managing microbial scalp disorders by improving drug penetration and stability compared to conventional treatments.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” The authors discuss that antifungal hair serums with essential oils and herbal extracts show promise for managing microbial scalp disorders, as they might enhance drug delivery and patient adherence compared to traditional treatments like Ketoconazole, which can have side effects and limited effectiveness.
This article discusses ongoing research efforts to develop natural anti-androgenetic alopecia treatments using bioactive compounds from medicinal plants but reports no new clinical results.
434 citations
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October 2003 in “PTR. Phytotherapy research/Phytotherapy research” This review discusses the use of natural products in cosmetic preparations for skin and hair care, but reports no new research results.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” The abstract for Roota Hair Growth describes a product combining botanical extracts with clinically-tested ingredients to target hair thinning, breakage, and scalp fatigue by blocking DHT, strengthening hair fibers, and revitalizing the scalp through a precision roll-on applicator, offering a natural alternative for healthier hair.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” The investigators highlighted Roota Hair Growth as a promising botanical solution for hair concerns, suggesting it may improve hair health by addressing the root causes of thinning, breakage, and scalp fatigue.
3 citations
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March 2020 in “Zenodo (CERN European Organization for Nuclear Research)” This review discusses the use of various medicinal plants for promoting hair growth, highlighting traditional reports alongside clinical and scientific evidence, but reports no new clinical results.
2 citations
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November 2024 in “GSC Biological and Pharmaceutical Sciences” This article outlines the evolving role of cosmetics in enhancing confidence and attractiveness, highlighting their ability to address skin and hair concerns with active ingredient serums.
1 citations
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April 2025 in “Revista científica FACS.” This study explored the potential use of natural ingredients in managing alopecia areata, investigating their safety and efficacy as alternatives to conventional chemical treatments.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study formulated and evaluated herbal hair oils using traditional medicinal plants known for their nourishing and growth-promoting properties, finding that comprehensive evaluation is crucial for the standardization and scientific validation of these products as safe alternatives to synthetic hair care options.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This source outlines Roota Hair Growth Serum® as a premium product combining natural ingredients and scientific research to target hair thinning and promote scalp health, claiming a positive impact on hair regrowth when used consistently over time.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This source describes Roota Hair Growth Serum® as a product designed to promote natural hair regrowth by improving scalp health and strengthening hair strands through a blend of natural ingredients and advanced hair-growth technology, supported by clinical testing.
December 2023 in “International Journal For Multidisciplinary Research” This source reviews the application of various natural substances, particularly plant extracts from the Ayurvedic system, in promoting hair growth, addressing common issues like pigmentation, dandruff, and hair loss.
December 2023 in “International Research Journal of Modernization in Engineering Technology and Science” This study reviews the use and benefits of herbal cosmetics in addressing common hair issues like baldness, hair fall, and dandruff, highlighting that herbal products may offer fewer side effects than conventional beauty products.
September 2024 in “Journal of the American Academy of Dermatology” Natural extracts like kombucha, marine enzymes, and prebiotics can improve and restore damaged skin.
67 citations
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June 2018 in “Engineering in Life Sciences” This review discusses advancements in plant cell culture technology for producing potent natural cosmetic ingredients and reports no new experimental results.
21 citations
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November 2023 in “Heliyon” This review explored the use of six tropical plants, such as Acacia concinna and Garcinia mangostana, as natural active ingredients in shampoos, highlighting their beneficial physicochemical properties and biological activities for hair care and scalp maintenance.
June 2024 in “Journal of Drug Delivery Science and Technology” This review highlights that nanocarrier-based formulations, using both synthetic drugs and natural components, show promise in overcoming the limitations of current androgenetic alopecia treatments with modified release profiles and enhanced drug delivery, though clinical trials remain limited.
This study evaluated the stability of multiple active ingredients in TrichoSol™ for use in alopecia treatments, finding varying stability durations at room temperature—up to 180 days for some ingredients—supporting its use as a compounding vehicle in personalized therapies.