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The genes KRT25 and SP6 affect curly hair in horses, with KRT25 also causing hair loss. If both genes are mutated, the horse gets curly hair and hair loss. KRT25 can hide the effect of SP6.

Mutations in specific keratin genes cause improper hair structure in mice due to faulty keratin protein assembly.

Keratin proteins in epithelial cells are dynamic and crucial for cell processes and disease understanding.

Childhood hair and scalp disorders can be managed with treatments like cortisone and corticosteroids.

New treatments targeting specific genes show promise for treating keratin disorders.

Too much β-catenin activity can mess up the development of mammary glands and make them more like hair follicles.

The research identified genes that explain why some sheep have curly wool and others have straight wool.

Wnt signaling is crucial for skin development and hair growth.

The document concludes that over 500 genes are linked to hair disorders and this knowledge is important for creating new treatments.

The hair follicle infundibulum plays a key role in skin health and disease, and understanding it better could lead to new skin disease treatments.

Sweat gland development involves two unique skin cell programs and a temporary skin environment.

Scientists turned mouse stem cells into skin cells that can grow into skin layers and structures.

Human hair keratins K85 and K35 create unique filament patterns important for early hair formation.

Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.

Different types of skin cells play specific roles in development, healing, and cancer.

The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.

SA linked to mitochondrial issues and oxidative stress, while AGA involves disrupted hair growth genes.

Trichoscopy is a useful tool for diagnosing hair disorders without pulling out hair.

Future hair cosmetics will be safer and more effective.

UV photography can help identify people at higher risk for skin cancer, and male pattern baldness at age 45 is linked to a higher risk of certain skin cancers.

Mirex seems to promote a unique group of skin cells different from those affected by another tumor promoter, TPA.

Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.

Activating Wnt in skin cells controls the number of hair follicles by directing cell movement and fate.

The scraggly mutation causes hair loss and skin defects in mice.

Stopping mitochondrial respiration can prevent brain cancer spread in skin cancer patients, and plant compound β-sitosterol could help achieve this.

Some mutant mice have hair with abnormal cross-linking, mainly in the cuticle, not affecting other hair parts.

Phospholipase A2 is necessary for the correct placement of PIN proteins in plant roots, affecting root growth.

Afatinib, neratinib, and zanubrutinib could be effective against KRASG12C-mutant tumors.

TGFα gene mutation in mice causes abnormal skin, wavy hair, curly whiskers, and sometimes eye inflammation.

The G60S Connexin43 mutation causes hair growth issues and poor hair quality in mice, similar to human ODDD patients.