Scraggly: A New Hair Loss Mutation on Mouse Chromosome 19
September 1999
in “
Mammalian genome
”
Studysummary In this study, researchers generated a mouse mutation called scraggly, related to hair and skin defects, and mapped it to a genetic location on mouse Chromosome 19 distinct from similar mutations. Our plain-language summary of this paper — not a Tressless recommendation.
The study identified a new mouse mutation called scraggly (sgl) induced by chlorambucil, which caused hair loss, skin defects, and abnormalities in sebaceous lipid composition in homozygous mutant mice. Researchers created a high-resolution genetic map of mouse Chromosome 19, linking the sgl mutation to the DNA marker D19Umi1. Further mapping using a cross between BALB/c and CAST/Ei mice helped locate markers around the mutation and potential candidate genes, Fgf8 and Cyp17. Allelism tests confirmed that sgl and another hair loss mutation, asebia (ab), were distinct genes.
