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The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Oestrogens are key for bone growth during puberty in both boys and girls.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Stem cell niches support, regulate, and coordinate stem cell functions.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

The AUTS2 gene is linked to neurological disorders and may affect human brain development and cognition.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Grafted rodent and human cells can regenerate hair follicles, but efficiency decreases with age.

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

The article concludes that better understanding gene regulation related to seasonal changes can offer insights into the mechanisms of seasonal timing in mammals.

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.