September 2022 in “Research Square (Research Square)” This study found that a specific gene mutation was identified in a family with monilethrix, and treatment with 5% minoxidil liniment improved hair quality in the proband without adverse events.
August 2022 in “JAAD case reports” This case report describes a 36-year-old woman with hidradenitis suppurativa whose condition progressed to rapidly fatal squamous cell carcinoma, highlighting the potential for aggressive tumor development linked to specific protein markers.
September 2024 in “Dokumentenrepositorium der RUB (Ruhr University Bochum)” This study found that patients with higher baseline monocyte counts (\(\geq\) 925/\(\mu\)l) were significantly more likely to see treatment failure with adalimumab for hidradenitis suppurativa.
67 citations
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November 2019 in “Nature Communications” This study demonstrated that a c-Kit-CreER-driven mouse model confirms melanocyte stem cells as a genuine source of melanoma, paralleling human melanoma in heterogeneity and gene signatures.
This study reports that topical 5% minoxidil solution significantly increased total hair counts and hair diameter in Korean men with androgenetic alopecia over 24 weeks and was well tolerated.
15 citations
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March 2023 in “BioMed” This review discusses multisystem inflammatory syndrome in adults (MIS-A) related to SARS-CoV2 and outlines the existing knowledge and unanswered questions, reporting no new clinical results.
May 2024 in “IP Journal of Nutrition Metabolism and Health Science” This study found that an educational program significantly improved knowledge about polycystic ovary syndrome and its prevention among adolescent girls at a selected college.
January 1999 in “Praxis sociológica” This study demonstrates that melanocyte stem cells can be a source of melanoma in a mouse model, resembling human melanoma in both heterogeneity and gene signatures.
2 citations
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August 2004 This study found that early diagnosis using gas chromatography/mass spectrometry and appropriate long-term treatment are crucial for improving outcomes in patients with methylmalonic acidemia.
January 2024 in “Frontiers in Bioengineering and Biotechnology” In this mouse study, researchers found that nanoparticles loaded with umbilical cord-derived stem cell membranes and minoxidil enhanced hair growth by improving drug solubility and transdermal delivery, increasing VEGF, IGF-1, MKI67, and CTNNB protein levels in skin tissue compared to regular minoxidil.
6 citations
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October 2001 in “British Journal of Ophthalmology” This article discusses the potential of intralesional cidofovir for treating SCC without systemic toxicity, noting that surgical excision remains the best treatment option; it reports no new clinical results.
11 citations
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July 2010 in “European Journal of Dermatology” In this study, researchers confirmed linkage of a form of hair-nail ectodermal dysplasia to chromosome 12 in a Pakistani family, suggesting a possible non-coding mutation in KRTHB5 or a mutation in an unknown gene.
6 citations
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January 2004 in “DNA Research” This study identified a nonsense mutation in the Sgkl gene as the cause of defective hair growth in a mutant mouse strain, implicating the SGKL signaling pathway in hair development.
47 citations
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June 1994 in “Experimental Cell Research” mHa2 and mHa3 keratins have different structures and roles in mouse hair and tongue tissues.
April 2013 in “Cancer Research” This study confirmed the presence of specific stem cell populations in SKH1 hairless mice skin, including CD34+/α6-integrin+ cells, which are important for investigating ultraviolet radiation-induced carcinogenesis.
11 citations
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September 2010 in “American Journal of Medical Genetics - Part A” This study reports a mutation in the U2HR gene causing Marie Unna hereditary hypotrichosis in a Turkish family and notes eyebrow loss as a diagnostic clue.
288 citations
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June 2009 in “Human reproduction update” This review examines various methods for assessing hair growth in women, highlighting the usefulness of the mFG visual scoring method for diagnosing hirsutism despite its limitations.
June 2024 in “British Journal of Dermatology” This case report highlights the diagnosis of folliculotropic mycosis fungoides in a 15-year-old boy with atypical skin and hair follicle changes, a rare occurrence in pediatric patients.
32 citations
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February 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports the cloning and sequencing of two type II hair-specific keratin genes, ghHb1 and ghHb6, located on chromosome 12q13, which are expressed during hair growth.
June 2022 in “Biomedical reports” This study concluded that STK11 gene polymorphisms were not predictive of metformin response in women with PCOS, though they may influence alopecia and hirsutism.
In this study, researchers evaluated hirsutism in young females aged 18-24 using the modified Ferriman-Gallwey scoring system, finding that 52% showed mild to moderate-to-severe symptoms, often linked to menstrual irregularities and underlying endocrine disorders like polycystic ovary syndrome and thyroid issues.
19 citations
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May 2004 in “The American Journal of Dermatopathology” In this study, scalp biopsies from HJMD patients revealed histological similarities to chronic telogen effluvium and highlighted the role of CDH3 mutations disrupting normal hair cycles.
January 2026 in “Medicina” This study conducted among medical students in Saudi Arabia found a 37.2% prevalence of premature hair graying and associated it with smoking, a keto diet, hair coloring, and family history, while suggesting that lifestyle changes may reduce its impact.
2 citations
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December 2022 in “Archives of Dermatological Research” In this study, researchers developed a new classification system for anterior hairline types among Asian males without androgenetic alopecia, finding MM, RM, and ML to be the most common types.
January 2014 in “Max Planck Digital Library” This research describes mouse models to explore Kindlin-1's role in skin disorders, including Kindler syndrome, revealing novel integrin-independent pathways potentially leading to skin tumors.
In the Ovulation and Menstruation Health Pilot Study, multimodal recruitment strategies effectively increased racial diversity and survey completion rates for studying menstrual disorders like PCOS.
September 2016 in “Journal of Dermatological Science” This study found that knockout mice lacking SMS1 showed reduced body weight and hair loss, indicating a role for SMS1 in normal growth and hair health.
119 citations
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January 2000 in “British Journal of Dermatology” This study found that keratin expression patterns vary within nail unit structures, with the nail matrix uniquely expressing the acidic hair-type keratin Ha1.
12 citations
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February 2022 in “Acta Biomaterialia” In this study, researchers found that dissolving microneedles made with hyaluronic acid enhanced the effectiveness of minoxidil in reducing hair loss and promoting hair growth in alopecia-affected mice more effectively than topical minoxidil alone, while using only 10% of the drug amount.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that in a mouse model of Focal Dermal Hypoplasia, treatment with lithium carbonate improved skin disease symptoms compared to controls, though disease severity varied and posed interpretation challenges.