Roles of Two Sphingomyelin Synthase Isoforms in Murine Hair

September 2016 in “ Journal of Dermatological Science ”

Takeshi Ichikawa, Akihito Nishi, Shota Sakai, Asami Makino, Yoshihiro Tokudome, Tadashi Yamashita, Toshiro Okazaki, Yoshikazu Uchida, Takaaki Tsuchida, Yoshio Hirabayashi, Sumiko Hamanaka

sphingomyelin synthase SMS1 SMS2 anagen phase hair cycle hair growth

Studysummary This study found that knockout mice lacking SMS1 showed reduced body weight and hair loss, indicating a role for SMS1 in normal growth and hair health.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

View this study on jdsjournal.com →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

research Sphingolipids of the Murine Hair

1 citations , January 2012 in “Journal of The Society of Japanese Women Scientists”

This study analyzed the lipid composition of mouse hair, focusing on sphingolipids, and found significant differences in ceramides, glucosylceramides, and sphingomyelins between hair follicles and hair shafts.

research Serine-rich ultra high sulfur protein gene expression in murine hair and skin during the hair cycle

1 citations , February 1991 in “Journal of Biological Chemistry”

research 256 Expression patterns of the Siah genes in postnatal mouse skin

September 2017 in “Journal of Investigative Dermatology”

This study found that the expression levels of Siah1 and Siah2 in mice skin vary dynamically during postnatal hair follicle development, suggesting their specific roles in modulating the HIF pathway.

research Sphingolipid metabolism orchestrates establishment of the hair follicle stem cell compartment

4 citations , January 2025 in “The Journal of Cell Biology”

This study found that deleting ceramide synthase 4 in skin epidermis stem cells disrupts hair follicle and skin barrier function, leading to immune responses similar to atopic dermatitis, due to imbalances in lipid composition affecting differentiation.

research `Cyclic alopecia' inMsx2mutants: defects in hair cycling and hair shaft differentiation

158 citations , December 2002 in “Development”

In this study, Msx2-deficient mice showed progressive hair loss due to shortened anagen phase and prolonged catagen and telogen phases, resulting in cyclic alopecia with structurally abnormal hair shafts.