12 citations
,
March 2016 in “Life Sciences” This review discusses the potential of combined therapy with WP 631 and epothilone B for ovarian cancer, but reports no new clinical results.
68 citations
,
January 2022 in “International Journal of Molecular Sciences” This review summarizes factors involved in polycystic ovary syndrome pathogenesis and management, highlights commonly prescribed and repurposed medications, and calls for well-designed clinical trials to evaluate these treatments further.
9 citations
,
December 2020 in “Dermatologic Therapy” This review found that oral and topical phosphodiesterase inhibitors and topical prostaglandin analogues are safe and effective treatments for various skin diseases, including psoriasis, atopic dermatitis, vitiligo, and alopecia.
31 citations
,
September 2020 in “Clinical endocrinology” This review found limited evidence on the effectiveness of different antiandrogens for feminization in transgender women, suggesting cyproterone acetate, leuprolide, and medroxyprogesterone acetate may better suppress testosterone than spironolactone or estradiol alone.
January 2026 in “Nutrients” This systematic review found that probiotic supplementation improved sleep quality, reduced depressive symptoms, and enhanced aspects of quality of life in women with PCOS, though the findings are limited by a small number of studies and variable methods.
3 citations
,
July 2009 in “Experimental and Clinical Endocrinology & Diabetes” In this study, Buserelin nasal spray significantly reduced hirsutism scores and suppressed ovarian steroid secretion in women with non-adrenal hirsutism over six months, with effects lasting post-treatment.
May 2026 in “Reviews in Endocrine and Metabolic Disorders” This review explores weight loss interventions during gestation, emphasizing incretin-based therapies' potential to enhance reproductive health and address metabolic changes for better maternal and fetal outcomes.
August 2023 in “International journal of reproduction, contraception, obstetrics and gynecology” This study found that combining letrozole with metformin was more effective at inducing pregnancy in women with PCOS compared to letrozole alone, while OCP and metformin significantly improved menstrual regularity and reduced hyperandrogenic symptoms.
47 citations
,
November 2002 in “Journal of Neurochemistry” This study found that progesterone pretreatment in rats potentiated the effect of ethanol on mesocortical dopamine levels, suggesting an influence of neuroactive steroids on ethanol's action.
57 citations
,
January 1995 in “The American journal of medicine” This study discusses the use of oral contraceptives as a treatment for hyperandrogenism, showing improvement in hirsutism and acne for many women and possibly providing metabolic benefits with certain formulations.
6 citations
,
March 2024 in “Saudi Pharmaceutical Journal” This study found that a nano-cubosome formulation co-loaded with capsaicin and thiocolchicoside enhanced bioavailability and showed promising analgesic and anti-inflammatory effects in rats, potentially benefiting gout management through improved transdermal delivery.
16 citations
,
November 2017 in “Acta dermato-venereologica” This review examines how different prostanoids and their receptors affect hair growth but provides no new clinical results; it highlights potential implications for treating hair disorders.
3 citations
,
March 2018 in “Pediatric Dermatology” This study found that omeprazole can cause acquired generalized hypertrichosis by significantly increasing duodenal prostaglandin E2 synthesis, which is involved in hair growth regulation.
April 2024 in “Pharmaceuticals” This review highlights the clinical usefulness of bimatoprost in lowering intraocular pressure for glaucoma patients and its promising results in promoting hair growth for conditions like alopecia, with research also exploring potential new applications and delivery systems.
December 2025 in “Brazilian Journal of Chemical Engineering”
5 citations
,
January 2020 in “in Vivo” This study found that administering testosterone to pregnant rats altered connexin 26 and connexin 43 expression in the uterus, which could disrupt embryo implantation and cause early pregnancy loss.
67 citations
,
March 2018 in “The Journal of Clinical Endocrinology & Metabolism” This study reported that estrogen-progestin oral contraceptives, antiandrogens, and insulin sensitizers are more effective than placebo in treating hirsutism in women, with combination therapies generally proving superior to monotherapy.
January 2007 in “Inpharma Weekly” Dutasteride is more effective for male pattern baldness than finasteride, and black cohosh extract BNO 1055 is as effective as conjugated estrogens in treating postmenopausal symptoms, with added benefits in reducing sweating and mental symptoms.
July 2011 in “مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام” Testosterone reduces, while finasteride enhances, morphine's pain relief.
1 citations
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August 2013 in “Springer eBooks” Birth control pills and anti-androgen medications help manage hair growth, acne, and hair loss in women with PCOS.
November 2008 in “Cancer Prevention Research” This article reviews pivotal trials and recent findings in chemoprevention for breast, prostate, and colorectal cancers, emphasizing its potential and the importance of further research, public education, and partnerships, but reports no new results.
December 1989 in “Inpharma (Balgowlah)” Cyproterone helps women with hair loss caused by genetics. More research is needed to confirm the best dose.
18 citations
,
December 2017 in “Medicine” This study found that combining celecoxib with chemotherapy improved overall survival, disease-free survival, and quality of life in gastric cancer patients with positive COX-2 expression without increasing adverse events.
November 2007 in “Neuro-chirurgie/Neurochirurgie” This study reported that treatment with cyproterone acetate alone and then with incremental estrogen doses induced mild feminizing effects in late-pubertal trans-girls, with further feminization observed after adding estrogen.
September 2023 in “Biology of reproduction” This study suggests that the testosterone analogs 7α-Methyltestosterone and 7α-Ethyltestosterone may offer promising androgenic, progestogenic, and anabolic properties for development as male contraceptives.
75 citations
,
June 2005 in “Archives of Dermatology” In this case report, a patient experienced a recurrence of alopecia areata while undergoing etanercept treatment, suggesting the drug may not effectively prevent this condition's return.
15 citations
,
May 2009 in “Steroids” This study found that progesterone derivatives with chlorine or bromine substituents were effective in inhibiting 5α-reductase activity in human prostate and exhibited antiandrogenic effects in hamster flank organs.
May 2026 in “Journal of Functional Foods” In this study of women with polycystic ovary syndrome, 12 weeks of daily ginger supplementation significantly reduced total testosterone and improved menstrual irregularities compared to placebo, suggesting potential as a natural therapeutic approach, although larger studies are needed.
29 citations
,
March 2017 in “International Journal of Women's Dermatology” This review found that combined oral contraceptives and spironolactone are effective treatments for adult acne in women, but noted that oral contraceptives increase the risk of venous thromboembolism and require individual risk assessment before use.
129 citations
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January 1977 in “Hormone and metabolic research” Cyproterone Acetate effectively treats androgen-related conditions and is used in prostate cancer therapy and hormone therapy for transgender women.