106 citations
,
September 2010 in “Stem cells” This study found that skin-derived precursor cells in mice can originate from both neural crest and somite lineages but show functional similarities regardless of their developmental origins.
85 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”
80 citations
,
April 2011 in “Plant physiology” This study suggests that the GPX-PDE1 and GPX-PDE2 genes in white lupin enhance root hair development and contribute to Pi limitation acclimation by facilitating glycerophosphodiester degradation.
80 citations
,
January 1988 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study observed that high-dose spironolactone frequently caused metrorrhagia in women with idiopathic hirsutism, leading the authors to suggest lower starting doses or additional hormonal therapy.
75 citations
,
February 2016 in “The Journal of Sexual Medicine” This review highlights the efficacy of transdermal testosterone therapy in improving sexual function in women with hypoactive sexual desire disorder, though approved formulations and long-term safety data are limited.
57 citations
,
April 2009 in “Differentiation” This study demonstrates that SDF-1/CXCL12 and CXCR4 signaling play a crucial role in directing the migration and positioning of melanoblasts in mouse hair follicle formation.
56 citations
,
July 2014 in “PloS one” This study found that selective androgen receptor modulators (SARMs) significantly inhibited tumor growth and metastasis-promoting factors in AR-positive triple-negative breast cancer models.
53 citations
,
April 2021 in “Cell Host & Microbe” This study found that skin microbiota, particularly in wild-type mice, promotes wound-induced hair follicle neogenesis and wound healing, highlighting the potential downsides of routine antibiotic use on skin regeneration.
51 citations
,
September 2020 in “Nucleic Acids Research” This article introduces signatureSearch, a software package designed for gene expression signature searching and functional enrichment analysis, but reports no new clinical results.
47 citations
,
June 2019 in “Nature Communications” This study found that self-noncoding dsRNA activates TLR3 to stimulate intrinsic retinoic acid synthesis, promoting new hair follicle formation in wounded mice and showing similar gene expression changes in humans treated with rejuvenation lasers.
46 citations
,
October 2012 in “Seminars in reproductive medicine” This review describes how recent discoveries in genetic defects and alternative pathways in androgen biosynthesis are reshaping our understanding of male sexual differentiation, but it presents no new clinical findings.
46 citations
,
September 2010 in “Veterinary Dermatology” This retrospective study documented various skin diseases in alpacas, reporting bacterial infections as the most common, along with other conditions described for the first time.
40 citations
,
January 1973 in “Journal of Dairy Science” This study found that zinc deficiency in goats led to lower plasma zinc levels, decreased growth rate, smaller testicles, reduced libido, and was associated with higher mortality compared to control goats.
39 citations
,
May 2015 in “Advanced drug delivery reviews” This review discusses skin tissue engineering and highlights the potential role of microRNAs in improving bioengineered skin equivalents, concluding that further exploration of microRNA targets could address unmet clinical needs.
38 citations
,
October 2005 in “Expert opinion on therapeutic patents” This review discusses nonsteroidal selective androgen receptor modulators and their potential therapeutic applications but reports no new clinical findings.
35 citations
,
October 2014 in “Wound Repair and Regeneration” This study developed a validated murine model of hypertrophic scar contraction, demonstrating similarities to human skin and observing graft contraction and tissue characteristics over time.
35 citations
,
January 1990 in “PubMed” This study found that oral cyclosporin A increased hair growth in nude mice, while minoxidil did not have the same effect.
32 citations
,
September 2018 in “Journal of pharmaceutical sciences” This study extended a skin diffusion model to include a porous pathway, effectively explaining the permeability of both polar and lipophilic solutes through the stratum corneum.
28 citations
,
January 1997 in “Elsevier eBooks” Keratinocyte stem cells help regenerate and repair cornea, skin, and hair.
27 citations
,
October 2003 in “Journal of the American Academy of Dermatology” This case report describes white piedra infection of the scalp hair with a synergistic bacterial infection in two US native sisters, highlighting its relevance in diagnosing scalp hair concretions despite its rarity in North America.
27 citations
,
August 1999 in “Urology” This study found that finasteride improved urodynamic measures of obstruction in men with benign prostatic enlargement and lower urinary tract symptoms, with continued improvement over two years of treatment.
24 citations
,
November 2021 in “PLoS ONE” In this study, fractional laser treatment was observed to reverse age-related gene expression changes in skin and enhance dermal remodeling, further improved by multiple treatments.
23 citations
,
January 1991 in “Journal of Animal Science” In this study, dietary biotin supplementation showed no significant benefit on reproductive performance in sows or pre-weaning growth and mortality in piglets.
21 citations
,
May 1976 in “Archives of Dermatology” This article discusses perioral dermatitis and reports no new results; the authors present two cases implicating fluoride toothpaste as a potential cause.
20 citations
,
January 2012 in “Journal of Steroids & Hormonal Science” The document concludes that there are still unknowns about the effectiveness, risks, and detection of performance-enhancing drugs, and doping remains a challenge.
20 citations
,
June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery” This review summarizes recent research and patents on 17β-HSD3, 17β-HSD5, and 3α-HSD3 inhibitors, suggesting their potential in treating androgen-dependent diseases, but reports no new clinical results.
20 citations
,
September 2005 in “Endocrinology” This study identified novel selective androgen receptor modulators with enhanced in vivo pharmacological activity through structure-activity relationship analysis in castrated rats.
19 citations
,
November 2023 in “npj Regenerative Medicine” This study found that synthetic melanin particles applied topically in mouse injury models improved wound healing, showing potential as a therapy for accelerated healing, including in human skin explants.
19 citations
,
December 2006 in “Archives of dermatology” This notice provides information about JAMA Dermatology's website usage policy, and no research findings are reported.
18 citations
,
June 2008 in “Archives of Dermatology” This study found that a 60-second hair count is a reliable and consistent method to assess hair shedding in healthy men without alopecia.